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a Department of Public Health and Primary Care, University of Cambridge, United Kingdom
b Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland
David Melzer, Department of Public Health and Primary Care, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2SR, UK E-mail: dm214{at}medschl.cam.ac.uk.
Background. Disability reflects physiological limitations, social and environmental barriers, and "sickness" behavior. Being able to measure these influences separately would greatly assist interpretation of disability comparisons over time or between populations. This study aimed to identify an index of mobility-related limitations composed of physiological measures that are most closely associated with reported mobility disability in elders.
Methods. Data from the Third National Health and Nutrition Examination Survey (NHANES III) were used. Participants aged 60 and older were included in this analysis. Participants included 6596 respondents who were interviewed in their homes, and 5724 (87%) of these attended a further examination. Domains of measurements included body measurements, bone densitometry, physical examination, spirometry, fundus photography, and physical performance measures. Multivariate models were developed on a random half subsample of the data and were validated on the other half. Receiver operating characteristic (ROC) areas and logit rank slopes were used to evaluate sets of measures.
Results. In weighted logistic regression models, six and five measures were significantly associated with difficulty and inability in walking a quarter of a mile, respectively. These mainly included measures of lower extremity and lung function. A relatively minimal loss of sensitivity and specificity occurred from using more economical models, employing a subset of the identified measures.
Conclusions. Subsets of measures associated with reported mobility disability could provide objective indices of mobility-related limitation for comparing populations or long-term population health monitoring.
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  D. Melzer, M. G. Dik, G. J. van Kamp, C. Jonker, and D. J. Deeg The Apolipoprotein E e4 Polymorphism Is Strongly Associated With Poor Mobility Performance Test Results But Not Self-Reported Limitation in Older People J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2005; 60(10): 1319 - 1323. [Abstract] [Full Text] [PDF]
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J. E. Morley Editorial: Sarcopenia Revisited J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2003; 58(10): M909 - 910. [Full Text] [PDF]
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T.-Y. Lan, D. J. H. Deeg, J. M. Guralnik, and D. Melzer Responsiveness of the Index of Mobility Limitation: Comparison With Gait Speed Alone in the Longitudinal Aging Study Amsterdam J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2003; 58(8): M721 - 727. [Abstract] [Full Text] [PDF]
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J. E. Morley Editorial. Mobility Performance: A High-Tech Test for Geriatricians J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2003; 58(8): M712 - 714. [Full Text] [PDF]
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J. E. Morley The Need for a Men's Health Initiative J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2003; 58(7): M614 - 617. [Full Text] [PDF]
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J. E. Morley Editorial: Hot Topics in Geriatrics J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2003; 58(1): M30 - 36. [Full Text] [PDF]
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