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Searching for Human Longevity Genes

The Future History of Gerontology in the Post-genomic Era

^a Department of Medicine, Divisions of Geriatrics and Endocrinology, and the Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York
^b Division of Endocrinology, Diabetes, and Nutrition, University of Maryland, and the Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore

Nir Barzilai, Divisions of Geriatrics and Endocrinology, Department of Medicine, Belfer Building 701, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461 E-mail: barzilai{at}aecom.yu.edu.

Decision Editor: John E. Morley, MB, BCh

Over the last 30 years, a number of genetic and environmental factors that lead to decreased length of life have been identified. Unfortunately, much less progress has been achieved in identifying genes associated with longevity that protect from common diseases or slow the aging process. Recent compelling evidence supports a role for important genetic and environmental interactions on longevity in lower organisms. Although less is known in humans, commonality in molecular and biological processes, evolutionary arguments, and epidemiological data would strongly suggest that similar mechanisms also apply. The completion of the Human Genome Project and the rapid innovations in technology will make possible the identification of human longevity-assurance genes. This article reviews such evidence, its implications for the identification of human longevity-assurance genes, and the significance of finding longevity genes to human health and disease.

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