Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]
Author:
 		Keyword(s):
Year:  Vol:  Page: 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Beekman, M.
Right arrow Articles by Slagboom, P. E.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Beekman, M.
Right arrow Articles by Slagboom, P. E.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 61:355-362 (2006)
© 2006 The Gerontological Society of America

Chromosome 4q25, Microsomal Transfer Protein Gene, and Human Longevity: Novel Data and a Meta-Analysis of Association Studies

Marian Beekman, Gerard Jan Blauw, Jeanine J. Houwing-Duistermaat, Bernd W. Brandt, Rudi G. J. Westendorp and P. Eline Slagboom

1 Molecular Epidemiology, 2 Gerontology and Geriatrics, Department of General Internal Medicine, and 3 Medical Statistics, Leiden University Medical Center, The Netherlands.

Address correspondence to Marian Beekman, PhD, Leiden University Medical Center, Section of Molecular Epidemiology, P.O. Box 9503, 2300 RA Leiden, The Netherlands. E-mail: M.Beekman{at}LUMC.nl

Recently, chromosome 4q25 was linked to exceptional human longevity, and a haplotype of the positional candidate microsomal transfer protein (MTP) gene was associated to the phenotype in U.S. Caucasians. We investigated whether linkage to 4q25 could be detected in 164 nonagenarian sibships of the Leiden Longevity Study. Additionally, we compared the MTP –493G/T and Q95H allele and haplotype frequencies in the Leiden Longevity Study (379 nonagenarians, 525 of their offspring, and 251 partners of their offspring) and in the Leiden 85-Plus Study (655 octogenarians and 244 young controls). The latter study population was followed for at least 7 years, providing the opportunity to perform also prospective analyses using the longitudinal data. We found neither evidence for linkage at 4q25 nor association of the MTP locus with longevity in nonagenarian individuals. Meta-analyses of all previous studies implied that the association in U.S. Caucasians may have its source in admixture of the U.S. control population rather than in the genetic effect of the locus on exceptional longevity.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
All GSA journals The Gerontologist
Journals of Gerontology Series B: Psychological Sciences and Social Sciences
Copyright © 2006 by The Gerontological Society of America.