Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]
Author:
Keyword(s):
Year:  Vol:  Page: 


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Magwere, T.
Right arrow Articles by Partridge, L.
Right arrow Articles citing this Article
PubMed
Right arrow PubMed Citation
Right arrow Articles by Magwere, T.
Right arrow Articles by Partridge, L.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 61:136-145 (2006)
© 2006 The Gerontological Society of America

Flight Activity, Mortality Rates, and Lipoxidative Damage in Drosophila

Tapiwanashe Magwere, Reinald Pamplona, Satomi Miwa, Pedro Martinez-Diaz, Manuel Portero-Otin, Martin D. Brand and Linda Partridge1,

1 Department of Biology, University College London, United Kingdom.
2 Department of Basic Medical Sciences, Faculty of Medicine, University of Lleida, Spain.
3 MRC Dunn Human Nutrition Unit, Cambridge, United Kingdom.

Address correspondence to Professor Linda Partridge, DPhil, University College London, Department of Biology, Darwin Building, Gower Street, London WC1E 6BT, U.K. E-mail: l.partridge{at}ucl.ac.uk

In this study, the effect of flight activity on mortality rates and lipoxidative damage in Drosophila was determined to identify mechanisms through which oxidative damage affects life span. The results showed that flies allowed flying throughout life had higher mortality rates and decreased median and maximum life spans compared to controls. The mortality rate of the flight activity group could be lowered, but not completely reversed by switching to control conditions; and the accrued oxidative damage could not be eliminated. The levels of reactive oxygen species produced by mitochondria isolated from high activity and control flies did not differ significantly. However, the high activity flies had altered membrane fatty acid compositions, which made them prone to increased lipid peroxidation. The effect of flight activity on insect life span differs considerably from the beneficial effects of exercise in mammals; these differences may be caused by physiological differences between the two taxa.







HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
All GSA journals The Gerontologist
Journals of Gerontology Series B: Psychological Sciences and Social Sciences
Copyright © 2006 by The Gerontological Society of America.