Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 60:1212-1218 (2005)
© 2005 The Gerontological Society of America

Postexercise Nutrient Intake Enhances Leg Protein Balance in Early Postmenopausal Women

Lars Holm1,, Birgitte Esmarck2, Charlotte Suetta1, Keitaro Matsumoto3, Tatsuya Doi3, Masao Mizuno4, Benjamin F. Miller1 and Michael Kjaer1

1 Institute of Sports Medicine, Copenhagen, Bispebjerg Hospital, Denmark.
2 Copenhagen Muscle Research Centre, Rigshospitalet, Denmark.
3 Saga Nutraceuticals Research Institute, Otsuka Pharmaceutical, Saga, Japan.
4 Research Unit 247, Ribe County Hospital Esbjerg, Esbjerg, Denmark.

Address correspondence to Lars Holm, Institute of Sports Medicine, Copenhagen, Bld. 8 1st Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark. E-mail: lh17{at}bbh.hosp.dk

Background. We investigated the effect of nutrient administration after a session of resistance exercise on muscle protein kinetics in six healthy, early postmenopausal women, in a crossover design of random and double-blinded administration of protein and carbohydrate (PC) or placebo (NON).

Methods. Fasted participants received a primed-constant infusion of L-[ring-2H5]-phenylalanine. After 90 minutes of rest, the participants performed leg-resistance exercises followed by the oral supplementation. During the following 4 hours, net protein balance (NB) and rate of disappearance and appearance of phenylalanine were calculated from arterial–venous blood samples and blood flow measurements.

Results. NB was elevated (p <.001) in the PC group compared to the NON group, and NB was not different from zero in the PC group, whereas it was negative in the NON group. Net balance results were supported by kinetic data from a reduced number of participants, showing that rate of disappearance was responsible for the initial (<1 hour) effect of PC, whereas a reduced rate of appearance enhanced the NB from 1.5 to 3 hours after training in the PC group.

Conclusion. In early postmenopausal women, nutrient ingestion following resistance exercise improved anabolism by enhancing NB in skeletal muscle.






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