Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 60:1125-1131 (2005)
© 2005 The Gerontological Society of America

REVIEW ARTICLE

Dietary Restriction in the Nematode Caenorhabditis elegans

Koen Houthoofd1, Thomas E. Johnson2 and Jacques R. Vanfleteren1,

1 Department of Biology, Ghent University, Belgium.
2 Institute for Behavioral Genetics, Department of Integrative Physiology, University of Colorado at Boulder.

Address correspondence to Jacques R. Vanfleteren, Department of Biology, Ghent University, K.L. Ledeganckstraat 35, B-9000 Ghent, Belgium. E-mail: Jacques.Vanfleteren{at}UGent.be

The first observation of the positive effect of reduced food intake on mammalian life span was made 70 years ago ( 1). In the decades that followed, researchers successfully applied this method to increase the life span of a very wide range of animals. The nematode Caenorhabditis elegans is an excellent model organism for studying the aging process. However, relatively little effort has been made to study the effects of dietary restriction in C. elegans. In this review we discuss the difficulties of subjecting C. elegans to dietary restriction, the effects of dietary restriction on metabolism and stress defense, and the potential role of different signaling pathways in DR-induced life extension. Recent experiments suggest that the TOR (target of rapamycin) pathway, rather than insulin-like signaling, might be involved in mediating the life-extending effect of dietary restriction.




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N. J. Szewczyk, I. A. Udranszky, E. Kozak, J. Sunga, S. K. Kim, L. A. Jacobson, and C. A. Conley
Delayed development and lifespan extension as features of metabolic lifestyle alteration in C. elegans under dietary restriction
J. Exp. Biol., October 15, 2006; 209(20): 4129 - 4139.
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