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Coenzyme Q₁₀ Protects From Aging-Related Oxidative Stress and Improves Mitochondrial Function in Heart of Rats Fed a Polyunsaturated Fatty Acid (PUFA)-Rich Diet

Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, Spain.

Address correspondence to Dr. Julio J. Ochoa, Institute of Nutrition and Food Technology, C/Ramón y Cajal, 4, 18071 Granada, Spain. E-mail: jjoh{at}ugr.es

Coenzyme Q₁₀ supplementation on age-related changes in oxidative stress and function of heart mitochondria in rats fed a polyunsaturated fatty acid (PUFA)-rich diet was investigated. Two groups of rats were fed for 24 months on a PUFA-rich diet, differing in supplementation or not with coenzyme Q₁₀. Animals were killed at 6, 12, or 24 months. Fatty-acid profile, hydroperoxides, -tocopherol, coenzyme Q, catalase and glutathione peroxidase activities, and cytochromes a+a₃, b, c+c₁ and cytochrome c oxidase activity were measured. Coenzyme Q₁₀-supplemented animals showed lower hydroperoxide levels; higher content and/or activity of -tocopherol, coenzyme Q, and catalase; and a slightly lower decrease in mitochondrial function. According to that, previously reported positive effects of coenzyme Q supplementation on the life span of rats fed a PUFA-rich diet might be a consequence, at least in part, of a lower oxidative stress level and perhaps, to a minor extent, of a smaller decrease in mitochondrial function.