Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 60:285-292 (2005)
© 2005 The Gerontological Society of America

Mismatch Repair System and Aging: Microsatellite Instability in Peripheral Blood Cells From Differently Aged Participants

Simona Neri1, Alessandro Gardini1, Andrea Facchini1,2, Fabiola Olivieri3, Claudio Franceschi3,4, Giovanni Ravaglia5 and Erminia Mariani1,2,

1 Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, I.O.R., Bologna, Italy.
2 Dipartimento di Medicina Interna e Gastroenterologia, Università di Bologna, Italy.
3 Istituto Nazionale di Riposo e Cura per Anziani di Ancona, Italy.
4 Dipartimento di Patologia Sperimentale e centro Interdipartimentale "L. Galvani," Università di Bologna, Italy.
5 Dipartimento di Medicina Interna Cardioangiologia ed Epatologia, Università di Bologna, Italy.

Address correspondence to Erminia Mariani, MD, Istituto di Ricerca Codivilla Putti, IOR Via di Barbiano 1/10, 40136 Bologna, Italy. E-mail: marianie{at}alma.unibo.it

Age-related alterations of DNA repair could be involved in the accumulation of genetic damage with age. Few data suggest a possible alteration with age of the mismatch repair system, evidenced by the acquisition of microsatellite instability. We aimed to point out a possible implication of this repair system in the accumulation of genetic damage with age. Peripheral blood cell DNA from 226 participants, 110 young (25–35 years), 58 old (85–97 years), and 58 centenarian was analyzed at five polymorphic microsatellite loci (CD4, p53, VWA31, TPOX, and FES/FPS) to point out age-related instabilities or modifications in allele frequencies. FES/FPS microsatellite was the most instable, showing both the appearance of trizygosis in DNA from old participants and differences in allele patterns among age groups, thus indicating an association between increased microsatellite instability and aging, one of the possible causes of which being an impairment of mismatch repair system capacity with age.






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