Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 60:275-279 (2005)
© 2005 The Gerontological Society of America

A Complex Dietary Supplement Extends Longevity of Mice

Jennifer A. Lemon1,, Douglas R. Boreham2 and C. David Rollo1

1 Departments of Biology
2 Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada.

Address correspondence to Jennifer Lemon, Department of Biology, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1. E-mail: lemonja{at}mcmaster.ca

Key factors implicated in aging include reactive oxygen species, inflammatory processes, insulin resistance, and mitochondrial dysfunction. All are exaggerated in transgenic growth hormone mice (TGM), which display a syndrome resembling accelerated aging. We formulated a complex dietary supplement containing 31 ingredients known to ameliorate all of the above features. We previously showed that this supplement completely abolished the severe age-related cognitive decline expressed by untreated TGM. Here we report that longevity of both TGM and normal mice is extended by this supplement. Treated TGM showed a 28% increase (p <.00008) in mean longevity. An 11% increase in mean longevity was also significant (p <.002093) for treated normal mice, compared to untreated normal mice. These data support the hypothesis that TGM are a model of accelerated aging, and demonstrate that complex dietary supplements may be effective in ameliorating aging or age-related pathologies where simpler formulations have generally failed.




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