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Association of Interleukin-10 Promoter Single Nucleotide Polymorphisms –819 T/C and –592 A/C With Aging

¹ Department of Clinical Laboratory Science, ² Division of Laboratory, Yamaguchi University Hospital, Yamaguchi University School of Medicine, Japan.
³ Department of Oral and Maxillofacial Surgery, Yamaguchi University School of Medicine, Japan.

Address correspondence to Yuji Hinoda, MD, PhD, Department of Clinical Laboratory Science, Yamaguchi University School of Medicine, 1-1-1, Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan. E-mail: hinoda{at}yamaguchi-u.ac.jp

Increased inflammatory activity is known to accompany aging. Single nucleotide polymorphisms of inflammatory mediator genes might therefore affect the aging process. Relation of eight SNPs (tumor necrosis factor- [TNF-] –1031 T/C, interleukin-10 [IL-10] –819 T/C, IL-1ß –511 C/T, IL-6 –634 C/G, IL-18 –607 A/C, transforming growth factor-ß [TGF-ß] +869 C/T, matrix metalloproteinase-1 [MMP-1] –1607 1G/2G, and MMP-3 –1171 5A/6A) with age or gender was evaluated in 500 Japanese persons (mean age: 56.7 years old, range: 19–100) by the chi-square test. There was a significant association of IL-10 –819 T/C with age (p =.0026). The association remained significant after multivariate logistic regression analysis (odds ratio for an age interval for 1 year, 1.009; 95% CI, 1.002–1.016). Furthermore, the genotype distribution of IL-10 –819 T/C was completely consistent with that of –592 A/C. These data suggest that IL-10 –819 T/C and –592 A/C may be a promising candidate for an aging-related gene in a Japanese population.