Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]
Author:
 		Keyword(s):
Year:  Vol:  Page: 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Cited by other online articles
Google Scholar
Right arrow Articles by Masternak, M. M.
Right arrow Articles by Bartke, A.
Right arrow Articles citing this Article
PubMed
Right arrow PubMed Citation
Right arrow Articles by Masternak, M. M.
Right arrow Articles by Bartke, A.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 60:1238-1245 (2005)
© 2005 The Gerontological Society of America

Caloric Restriction Results in Decreased Expression of Peroxisome Proliferator-Activated Receptor Superfamily in Muscle of Normal and Long-Lived Growth Hormone Receptor/Binding Protein Knockout Mice

Michal M. Masternak1,, Khalid A. Al-Regaiey1, Marc Michael Del Rosario Lim1, Michael S. Bonkowski1, Jacob A. Panici1, Grzegorz K. Przybylski2 and Andrzej Bartke1

1 Departments of Internal Medicine and Physiology, Geriatrics Research, Southern Illinois University School of Medicine, Springfield.
2 Institute of Human Genetics in Poznan, Polish Academy of Sciences, Poznan, Poland.

Address correspondence to Michal M. Masternak, PhD, School of Medicine, Geriatrics Research, Department of Internal Medicine, 801 N. Rutledge, Springfield, IL 62794-9628. E-mail: mmasternak{at}siumed.edu

Resistance to growth hormone, reduced insulin-like growth factor 1 (IGF1) action, and enhanced insulin sensitivity are likely mediators of extended life span and delayed aging process in growth hormone receptor/binding protein knockout (GHR-KO) mice. Fat metabolism and genes involved in fatty acid oxidation are strongly involved in insulin action. Using real-time polymerase chain reaction and western blot we have examined expression of peroxisome proliferator-activated receptors (PPARs) and retinoid X receptor (RXR) genes in the skeletal muscle of normal and GHR-KO mice subjected to 30% caloric restriction. The results indicate that caloric restriction decreased the expression of PPAR{gamma}, PPAR{alpha}, and PPARß/{delta} which would lead to down-regulation of fat metabolism. This suggested metabolic change clearly does not affect whole-body insulin action. These findings suggest that whole-animal insulin sensitivity is not regulated through skeletal muscle insulin action.




This article has been cited by other articles: (Search Google Scholar for Other Citing Articles)


Home page
 J Gerontol A Biol Sci Med SciHome page
Z. Wang, K. A. Al-Regaiey, M. M. Masternak, and A. Bartke
Adipocytokines and Lipid Levels in Ames Dwarf and Calorie-Restricted Mice
J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2006; 61(4): 323 - 331.
[Abstract] [Full Text] [PDF]

Home page
 J Gerontol A Biol Sci Med SciHome page
M. M. Masternak, K. A. Al-Regaiey, M. M. Del Rosario Lim, V. Jimenez-Ortega, J. A. Panici, M. S. Bonkowski, J. J. Kopchick, and A. Bartke
Effects of Caloric Restriction and Growth Hormone Resistance on the Expression Level of Peroxisome Proliferator-Activated Receptors Superfamily in Liver of Normal and Long-Lived Growth Hormone Receptor/Binding Protein Knockout Mice
J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2005; 60(11): 1394 - 1398.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
All GSA journals The Gerontologist
Journals of Gerontology Series B: Psychological Sciences and Social Sciences
Copyright © 2005 by The Gerontological Society of America.