Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 59:B876-B885 (2004)
© 2004 The Gerontological Society of America

Vascular Aging: Molecular Modulation of the Prostanoid Cascade by Calorie Restriction

Jung Won Kim1, Yani Zou1, Sik Yoon2, Ji Hyeon Lee1, Yoon Kyung Kim1, Byung Pal Yu3 and Hae Young Chung1,

1 Department of Pharmacy
2 College of Medicine, Aging Tissue Bank, Pusan National University, Kumjung-Ku, Busan, Korea.
3 Department of Physiology, University of Texas Health Science Center at San Antonio.

Address correspondence to Hae Young Chung, PhD, Department of Pharmacy, College of Pharmacy, Pusan National University, Kumjung-Ku, Busan 609-735, Korea. E-mail: hyjung{at}pusan.ac.kr

The relevance of prostanoids to inflammation, thrombosis, and cardiovascular diseases is well known. The present study attempts to explore age effects on prostanoids and their biosynthesis cascade. Results from comparing prostanoid levels between young (6 months) and old (24 months) Fischer 344 rats showed rises of prostaglandin E2 (PGE2), PGI2, and thromboxane A2 (TXA2) levels in the old rats. Correlating evidence showed gene expression up-regulation of several prostanoid synthase enzymes in old rat aorta. Further, we found that expression of the antioxidant enzyme glutathione peroxidase was raised by age in the aorta, while superoxide dismutase and catalase expression showed no significant change during aging in the aorta. Moreover, calorie restriction (CR) was found to attenuate age-related prostanoid changes by suppressing inflammatory activities. In conclusion, the data from this study indicated that age-related increases in prostanoids and their biosynthesis might be closely associated with a weakened antioxidant capacity.




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