Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]
Author:
 		Keyword(s):
Year:  Vol:  Page: 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Olfert, I. M.
Right arrow Articles by Mathieu-Costello, O.
Right arrow Articles citing this Article
PubMed
Right arrow PubMed Citation
Right arrow Articles by Olfert, I. M.
Right arrow Articles by Mathieu-Costello, O.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 59:B801-B808 (2004)
© 2004 The Gerontological Society of America

Oxygen Consumption During Maximal Exercise in Fischer 344 x Brown Norway F1 Hybrid Rats

I. Mark Olfert, Jamal Balouch and Odile Mathieu-Costello

Department of Medicine, Division of Physiology, University of California, San Diego.

Address correspondence to Mark Olfert, PhD, Department of Medicine 0623A, University of California–San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0623. E-mail: molfert{at}ucsd.edu

We characterized O2 consumption (VO2) during treadmill exercise in 12-, 24-, and 35-month-old Fischer 344 x Brown Norway F1 hybrid (F344BNF1) rats. When accounting for differences in body mass (Mb), VO2peak decreased by 10% and 33% in 24- and 35-month-old rats, respectively, compared with rats at 12 months (analysis of covariance, p <.01). O2 cost per unit work at VO2peak (i.e., VO2peak/work) was greater in 35-month-old rats compared with 12- and 24-month-old rats (p <.001). During submaximal exercise, the O2 cost was greater in 24- and 35-month-old than 12-month-old rats (p <.01). Analysis of covariance revealed similar patterns irrespective of differences in Mb or lean Mb as covariates. The underlying mechanism responsible for increasing O2 consumption in aged F344BNF1 rats during exercise, although partly explained by mechanical inefficiencies of locomotion, still remains to be determined.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
All GSA journals The Gerontologist
Journals of Gerontology Series B: Psychological Sciences and Social Sciences
Copyright © 2004 by The Gerontological Society of America.