Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 59:B784-B788 (2004)
© 2004 The Gerontological Society of America

Divergent Effects of Caloric Restriction on Gene Expression in Normal and Long-Lived Mice

Michal M. Masternak1,, Khalid Al-Regaiey1, Michael S. Bonkowski1, Jacob Panici1, Liou Sun1, Jian Wang1, Grzegorz K. Przybylski2 and Andrzej Bartke1

1 Departments of Internal Medicine and Physiology, Geriatrics Research, Southern Illinois University, School of Medicine, Springfield.
2 Institute of Human Genetics in Poznan, Polish Academy of Sciences, Poland.

Address correspondence to Michal M. Masternak, PhD, SIU School of Medicine, Department of Internal Medicine, Division of Geriatric Medicine, 801 N. Rutledge, Springfield, IL 62794-9628. E-mail: mmasternak{at}siumed.edu

Long-lived Ames dwarf mice share many phenotypic characteristics with animals subjected to caloric restriction (CR) but they are not CR mimetics. CR prolongs longevity in both normal and Ames dwarf mice. Using real-time polymerase chain reaction and western blot, we have examined the expression of genes related to insulin signaling in the liver of normal and dwarf mice subjected to 30% CR. The results revealed divergent responses of dwarf and normal animals to CR raising an interesting possibility that CR may affect longevity of normal and dwarf mice by different mechanisms. Moreover, effects of dwarfism on the expression of the examined genes differed from the effects of CR, thus adding to the evidence that these long-lived mutants are not CR mimetics.




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