Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]
Author:
 		Keyword(s):
Year:  Vol:  Page: 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Smith Sonneborn, J.
Right arrow Articles by Thomas, P.
Right arrow Articles citing this Article
PubMed
Right arrow PubMed Citation
Right arrow Articles by Smith Sonneborn, J.
Right arrow Articles by Thomas, P.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 59:B433-B440 (2004)
© 2004 The Gerontological Society of America

Alternative Strategy for Stress Tolerance: Opioids

Joan Smith Sonneborn1,, Henry Gottsch3, Eric Cubin3, Peter Oeltgen4 and Paul Thomas2

1 Department of Zoology & Physiology.
2 Department of Kinesiology & Health, University of Wyoming, Laramie.
3 School of Medicine, University of Washington, Seattle.
4 College of Medicine, University of Kentucky, Lexington.

Address correspondence to Joan Smith Sonneborn, Zoology & Physiology Department, University of Wyoming, Laramie, WY 82071-3166. E-mail: cancun{at}uwyo.edu

Endogenous opioids have been implicated in the pathway of tolerance to stresses. Hibernating tissues tolerate stress. Serum from hibernating woodchucks (hibernation induction trigger [HIT]), from summer nonhibernating animals (summer woodchuck active plasma [SWAP], and potential "hibernation opioid mimics" (D-Ala2 D Leu5 Enkephalin [DADLE]), and Deltorphin D (Delt D) were used as ischemic preconditioning agents (IPC) in an in vivo surgically induced cardiac ischemia rat model. Comparison of the IPC treatment was monitored by the molecular intensity of stress transcripts for polyubiquitin and HSP70 in Northern blot analyses. Delt D and HIT significantly reduced total polyubiquitin transcript expression, 2.1-fold and 1.4-fold, respectively, in ischemic tissue, while SWAP and DADLE did not differ from saline controls. The Delt D effect was sensitive to glibenclamide (Glb), a KATP (potassium adenosine triphosphate) channel blocker. No inducible HSP70 was detected. The demonstration of an opioid IPC modulation of the ubiquitin stress pathway found here may be relevant for development of drug intervention in heart attacks and stroke.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
All GSA journals The Gerontologist
Journals of Gerontology Series B: Psychological Sciences and Social Sciences
Copyright © 2004 by The Gerontological Society of America.