Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 59:1244-1250 (2004)
© 2004 The Gerontological Society of America

Hormone-Treated Snell Dwarf Mice Regain Fertility But Remain Long Lived and Disease Resistant

Maggie Vergara1, Michael Smith-Wheelock2, James M. Harper1, Robert Sigler3 and Richard A. Miller4,1,

1 Department of Pathology and Geriatrics Center
2 Department of Ophthalmology, University of Michigan, Ann Arbor.
3 Esperion Therapeutics, Ann Arbor, Michigan.
4 Ann Arbor Department of Veterans Affairs Medical Center, Ann Arbor.

Address correspondence to Richard A. Miller, Room 5316 CCGCB, Box 0940, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109–0940. E-mail: millerr{at}umich.edu

Snell dwarf mice have multiple hormonal deficits, but the way in which these deficits postpone aging are still uncertain. In this study, Snell dwarf mice received 11 weeks of growth hormone and thyroxine injections that increased their weight by approximately 45%, although they remained much smaller than controls. The hormone treatment also restored fertility to male dwarf mice. Despite these effects on growth and maturation, the hormone treatments did not diminish life span or lower the resistance of dwarf mice to cataracts and kidney disease. Administration of thyroxine in food throughout adult life did diminish longevity of Snell dwarf mice, although these mice remain longer lived than control animals. These results show that a 45% increase in body size does not impair longevity or disease resistance for dwarf mice of either sex, and that the exceptional longevity of Snell dwarf mice does not, at least for males, depend on prepubertal immaturity.




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