Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]
Author:
 		Keyword(s):
Year:  Vol:  Page: 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Roth, S. M.
Right arrow Articles by Ferrell, R. E.
Right arrow Articles citing this Article
PubMed
Right arrow PubMed Citation
Right arrow Articles by Roth, S. M.
Right arrow Articles by Ferrell, R. E.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 59:B10-B15 (2004)
© 2004 The Gerontological Society of America

Vitamin D Receptor Genotype Is Associated With Fat-Free Mass and Sarcopenia in Elderly Men

Stephen M. Roth1,2, Joseph M. Zmuda3, Jane A. Cauley3, Patrick R. Shea1 and Robert E. Ferrell1

1 Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pennsylvania.
2 Department of Kinesiology, College of Health and Human Performance, University of Maryland, College Park.
3 Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania.

We investigated the association of vitamin D receptor (VDR) genotype with fat-free mass (FFM) in a cohort of 302 older (aged 58–93 years) Caucasian men who underwent body composition analysis by dual-energy X-ray absorptiometry, and completed questionnaires addressing comorbidities, physical activity, and dietary intake. All participants were genotyped for a VDR translation start site (FokI) polymorphism [FF (37.7%), Ff (48.4%), and ff (13.9%)] and the previously studied BsmI polymorphism [BB (24.9%), Bb (37.7%), and bb (37.4%)]. The BsmI polymorphism was not associated with FFM in any analysis; however, the FokI polymorphism was significantly associated with total FFM, appendicular FFM, and relative (kg/m2) appendicular FFM (all p <.05), with the FF group demonstrating significantly lower FFM than the Ff and ff groups (e.g., total FFM: FF = 57.6 ± 0.4, Ff = 59.4 ± 0.4, ff = 59.4 ± 0.7 kg; p <.02). Age-adjusted logistic regression revealed a 2.17-fold higher risk for sarcopenia (defined previously as appendicular FFM <7.26 kg/m2) in FF homozygotes (95% CI [confidence interval] = 1.19–3.85; p =.03) compared to men with one or more f alleles. The VDR translation start site (FokI) polymorphism is significantly associated with FFM and sarcopenia in this cohort of older Caucasian men.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
All GSA journals The Gerontologist
Journals of Gerontology Series B: Psychological Sciences and Social Sciences
Copyright © 2004 by The Gerontological Society of America.