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Prevalence of Multivessel Coronary Artery Disease in Patients With Diabetes Mellitus Plus Hypothyroidism, in Patients With Diabetes Mellitus Without Hypothyroidism, and in Patients With No Diabetes Mellitus or Hypothyroidism

Cardiology Division, Westchester Medical Center/New York Medical College, Valhalla.

Background. We report the prevalence of significant multivessel coronary artery disease (CAD) (>50% stenosis) in patients with diabetes plus hypothyroidism, in patients with diabetes without hypothyroidism, and in patients without diabetes or hypothyroidism who had significant CAD documented by coronary angiography.

Methods. We performed a retrospective analysis in 100 patients selected randomly with significant CAD documented by coronary angiography to investigate the prevalence of significant multivessel CAD in patients with diabetes, in patients with hypothyroidism, and in patients without diabetes or hypothyroidism.

Results. Significant 3–4-vessel CAD was present in 9 of 10 patients (90%), mean age 73 ± 11 years, with diabetes plus hypothyroidism, in 10 of 25 patients (40%), mean age 63 ± 9 years, with diabetes without hypothyroidism, and in 10 of 65 patients (15%), mean age 68 ± 12 years, without diabetes or hypothyroidism (p <.001 comparing diabetes plus hypothyroidism with no diabetes or hypothyroidism; p <.01 comparing diabetes plus hypothyroidism with diabetes without hypothyroidism; and p <.02 comparing diabetes without hypothyroidism with no diabetes or hypothyroidism). Significant 2–4-vessel CAD was present in 10 of 10 patients (100%) with diabetes plus hypothyroidism, in 20 of 25 patients (80%) with diabetes without hypothyroidism, and in 37 of 65 patients (57%) with no diabetes or hypothyroidism (p <.01 comparing diabetes plus hypothyroidism with no diabetes or hypothyroidism; and p <.05 comparing diabetes without hypothyroidism with no diabetes or hypothyroidism).

Conclusions. In patients with diabetes mellitus plus hypothyroidism, the prevalence of 3-vessel or 4-vessel CAD was significantly higher than in patients with diabetes mellitus without hypothyroidism or in patients with no diabetes mellitus or hypothyroidism. In patients with diabetes mellitus without hypothyroidism, the prevalence of 3-vessel or 4-vessel CAD was significantly higher than in patients without diabetes mellitus or hypothyroidism.