Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 58:M648-M652 (2003)
© 2003 The Gerontological Society of America

Serum Sex Hormones, IGF-1, and IGFBP3 Exert a Sexually Dimorphic Effect on Lean Body Mass in Aging

Debra L. Waters, C. Lillian Yau, George D. Montoya and Richard N. Baumgartner

University of New Mexico–Health Sciences Center, Aging and Genetic Epidemiology Program, Albuquerque.

Background. Endogenous and exogenous sex hormones affect changes in body composition during aging via independent and dependent effects on the growth hormone/insulin-like growth factor–1 (GH/IGF-1) axis and associated binding proteins (BP).

Methods. Fasting serum IGF-1, IGFBP3, testosterone, estrone, and sex hormone binding globulin were analyzed in 48 women on hormone replacement (HRT) (unopposed oral estrogen, HRT+, ), 135 women not on HRT (HRT-, ), and 128 healthy men (men, ). Total lean body mass (LBM) and total fat were measured by dual energy X-ray absorptiometry.

Results. Total LBM decreased with age in all groups (). LBM was greater, and IGF-1, IGFBP3, and testosterone were lower in HRT+ versus HRT- women (, , , and , respectively). LBM in men was positively related to IGF-1 () and testosterone (), whereas LBM was associated with IGFBP3 () and total fat () in female HRT+ and total fat () in HRT– women. IGF-1 decreased with age in men and HRT- women () but did not decrease in HRT+ women. Total fat significantly decreased across age (). Controlling for age and HRT, the rate of decrease in fat was slower in men versus women (). IGFBP3 decreased in all groups across age (), and the ratio of IGF-1 to IGFBP3 decreased faster in men compared to HRT+ and HRT- women ().

Conclusions. Our data indicate divergent influences of sex steroids, IGF-1, and IGFBP3 on age-related changes in LBM in healthy elderly men and women.






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