HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Gresl, T. A. Articles by Kemnitz, J. W. Articles citing this Article PubMed PubMed Citation Articles by Gresl, T. A. Articles by Kemnitz, J. W.

Dietary Restriction and Beta-Cell Sensitivity to Glucose in Adult Male Rhesus Monkeys

¹ Wisconsin National Primate Research Center, Madison.
² Department of Biostatistics and Medical Informatics, University of Wisconsin–Madison.
³ Department of Physiology
⁴ Department of Nutritional Sciences
⁵ Department of Biostatistics, University of Alabama–Birmingham.

We examined the effects of dietary restriction (DR) and age on ß-cell function and peripheral insulin sensitivity in rhesus monkeys. A semipurified diet was provided either ad libitum for 8 hours/day to controls (C) or as 70% of baseline intake to restricted (R) animals for 10 years. The minimal model of C-peptide secretion and kinetics and the labeled 2-compartment minimal model of glucose kinetics were identified using plasma glucose, C-peptide, and insulin concentrations during an intravenous glucose tolerance test. R monkeys had less body fat, lower basal ß-cell sensitivity to glucose (Ø_b), greater insulin sensitivity, and lower first-phase plasma insulin response. DR did not significantly affect first-phase and second-phase ß-cell sensitivity to glucose. Indices of body fatness were highly predictive of the effect of DR on Ø_b, fasting insulin concentration and insulin responses to glucose. Enhanced peripheral insulin sensitivity among R monkeys was strongly correlated with lower Ø_b.