Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 58:B387-B393 (2003)
© 2003 The Gerontological Society of America

Age-Related Changes in Collagen, Pyridinoline, and Deoxypyridinoline in Normal Human Thoracic Intervertebral Discs

Celia I. Tan1, G. Neil Kent2, Andrew G. Randall2, Stephen J. Edmondston1 and Kevin P. Singer1

1 Centre of Musculoskeletal Studies, Department of Surgery, University of Western Australia.
2 Division of Clinical Pathology, The Western Australian Centre for Pathology and Medical Research (PathCentre), Queen Elizabeth II Medical Centre, Nedlands, Western Australia.

Human thoracic discs were analyzed for collagen and collagen cross-links to determine the distribution due to segmental, age, and gender influences. Thoracic discs from 26 cadaveric spines (1 to 90 years old) were graded macroscopically, then separated into anular and nuclear samples. Only grade I (i.e., normal) disc samples were selected (). Pyridinoline and deoxypyridinoline cross-links were initially separated by column chromatography and analyzed by reverse-phase high-pressure liquid chromatography. The collagen content was lower and the extent of pyridinoline and deoxypyridinoline were significantly higher in the nucleus compared with the anulus (). The collagen content and extent of pyridinoline were significantly lower with increasing age in the anulus and nucleus (). Young male discs had a significantly higher extent of pyridinoline compared with females (). Age, gender, and disc region differences were found to have a significant influence on the biochemical composition of the normal disc extracellular matrix.







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