Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 58:B1074-B1077 (2003)
© 2003 The Gerontological Society of America

Age-Dependent Decline of In Vitro Migration (Basal and Stimulated by IGF-1 or Insulin) of Human Vascular Smooth Muscle Cells

Antonio Ruiz-Torres1, Rosario Lozano1, José Melón2 and Raffaele Carraro1,3

1 University Research Institute of Ageing
2 Department of Cardiovascular Surgery
3 Department of Endocrinology, Hospital de la Princesa, Madrid, Spain.

Since biological aging causes a decrease in functions such as cell proliferation, we have studied the possible effect of age on the migration capacity of human vascular smooth muscle cells (SMCs). To this aim, the migration activity of cultured SMCs from arteries of male human donors ranging in age from 43–77 years was determined in a Boyden chamber, under basal conditions and after insulin-like growth factor-1 (IGF-1) or insulin stimulation. Migration activity decreased with donor age (r2 = 87%, 85%, and 78%, respectively). IGF-1 and insulin significantly reduced the age-dependent relationship observed in basal conditions, so that, comparing young with old, both IGF-1 and insulin stimulated SMC migration similarly, although the effect of age remained in absolute terms. In this article, we conclude that the age-dependent decline of migration activity—similar to what has already been shown for SMC proliferation—may be part of the biological ageing phenotype, which is not overcome by hormone stimulation.




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