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Testosterone Supplementation for Aging-Associated Sarcopenia

Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University, Los Angeles, California.

Aging of humans is associated with a loss of muscle mass and function, and an increase in fat mass. Epidemiologic studies have demonstrated a correlation between bioavailable testosterone concentrations and fat-free mass and muscle strength. Testosterone replacement in older men with low testosterone levels increases fat-free mass and muscle strength, and decreases fat mass. However, we do not know whether testosterone replacement improves physical function and other health-related outcomes, or reduces the risk of disability, falls, or fractures in older men with low testosterone levels. The long-term risks and benefits of testosterone supplementation in older men are not known.

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				A. B Newman, J. S. Lee, M. Visser, B. H Goodpaster, S. B Kritchevsky, F. A Tylavsky, M. Nevitt, and T. B Harris Weight change and the conservation of lean mass in old age: the Health, Aging and Body Composition Study Am. J. Clinical Nutrition, October 1, 2005; 82(4): 872 - 878. [Abstract] [Full Text] [PDF]