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Increased Prevalence of Peripheral Arterial Disease in Older Men and Women With Subclinical Hypothyroidism

Department of Medicine, Divisions of ¹ Geriatrics and
² Cardiology, Westchester Medical Center/New York Medical College, Valhalla.

Background. We report the prevalence of symptomatic peripheral arterial disease (PAD) associated with subclinical hypothyroidism in older persons.

Methods. We investigated the association of subclinical hypothyroidism with symptomatic PAD in 18 persons (16 women and 2 men) with subclinical hypothyroidism and in 231 euthyroid persons (151 women and 96 men), mean age 79 ± 9 years, in an academic nursing home.

Results. Symptomatic PAD was present in 14 of 18 persons (78%) with subclinical hypothyroidism and in 40 of 231 euthyroid persons (17%; p <.0001, comparing subclinical hypothyroidism with euthyroidism). Symptomatic PAD was present in 13 of 16 women (81%) and in 1 of 2 men (50%) with subclinical hypothyroidism (p was not significant).

Conclusions. Subclinical hypothyroidism was associated with a high prevalence of symptomatic PAD in elderly men and women.