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Is There an Antiaging Medicine?

^a International Longevity Center—USA, New York, New York.
^b Journal of Anti-Aging Medicine, Ada, Michigan
^c Kronos Longevity Research Institute, Phoenix, Arizona.
^d School of Public Health, University of Illinois, Chicago
^e Department of Geriatrics, Boston Medical Center, Massachusetts
^f Columbia College of Physicians and Surgeons and
^g Mailman School of Public Health, Columbia University, New York, New York
^h Biology of Aging Program, National Institute on Aging, Bethesda, Maryland.
ⁱ Advanced Cell Technology, Worcester, Massachusetts
^j Southwestern Medical Center, University of Texas, Dallas

Robert N. Butler, International Longevity Center—USA, 60 East 86th Street, New York, NY 10028 E-mail: robertb{at}ilcusa.org.

Decision Editor: James R. Smith, PhD

In spite of considerable hype to the contrary, there is no convincing evidence that currently existing so-called "antiaging" remedies promoted by a variety of companies and other organizations can slow aging or increase longevity in humans. Nevertheless, a variety of experiments with laboratory animals indicate that aging rates and life expectancy can be altered. Research going back to the 1930s has shown that caloric restriction (also called dietary restriction) extends life expectancy by 30–40% in experimental animals, presumably at least partially by delaying the occurrence of age-dependent diseases. Mutations that decrease production of insulin growth factor I in laboratory mammals, and those that decrease insulin-like signaling in nematodes and fruit flies, have increased life expectancy as well. Other general strategies that appear promising include interventions that reduce oxidative stress and/or increase resistance to stress; hormone and cell replacement therapies may also have value in dealing with specific age-related pathologies. This article reports the findings of a consensus workshop that discussed what is known about existing and future interventions to slow, stop, or reverse aging in animals, and how these might be applied to humans through future research.

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