Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]
Author:
Keyword(s):
Year:  Vol:  Page: 


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Cited by other online articles
Google Scholar
Right arrow Articles by Cypser, J. R.
Right arrow Articles by Johnson, T. E.
Right arrow Articles citing this Article
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cypser, J. R.
Right arrow Articles by Johnson, T. E.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 57:B109-B114 (2002)
© 2002 The Gerontological Society of America

Multiple Stressors in Caenorhabditis elegans Induce Stress Hormesis and Extended Longevity

James R. Cypsera and Thomas E. Johnsona

a Institute for Behavioral Genetics, University of Colorado, Boulder

Thomas E. Johnson, Institute for Behavioral Genetics, 1480 30th Street, Boulder, CO 80303 E-mail: johnsont{at}colorado.edu.

Decision Editor: John A. Faulkner, PhD

We demonstrate here that the nematode Caenorhabditis elegans displays broad hormetic abilities. Hormesis is the induction of beneficial effects by exposure to low doses of otherwise harmful chemical or physical agents. Heat as well as pretreatment with hyperbaric oxygen or juglone (a chemical that generates reactive oxygen species) significantly increased subsequent resistance to the same challenge. Cross-tolerance between juglone and oxygen was also observed. The same heat or oxygen pretreatment regimens that induced subsequent stress resistance also increased life expectancy and maximum life span of populations undergoing normal aging. Pretreatment with ultraviolet or ionizing radiation did not promote subsequent resistance or increased longevity. In dose-response studies, induced thermotolerance paralleled the induced increase in life expectancy, which is consistent with a common origin.




This article has been cited by other articles: (Search Google Scholar for Other Citing Articles)


Home page
Annals NYAS OnlineHome page
A. OLSEN, M. C. VANTIPALLI, and G. J. LITHGOW
Using Caenorhabditis elegans as a Model for Aging and Age-Related Diseases
Ann. N.Y. Acad. Sci., May 1, 2006; 1067(1): 120 - 128.
[Abstract] [Full Text] [PDF]


Home page
Genes & Dev.Home page
J. Apfeld, G. O'Connor, T. McDonagh, P. S. DiStefano, and R. Curtis
The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans
Genes & Dev., December 15, 2004; 18(24): 3004 - 3009.
[Abstract] [Full Text] [PDF]


Home page
SCI AGING KNOWL ENVIRONHome page
J. N. Sampayo and G. J. Lithgow
S.W.A.T.--SOD Weapons and Tactics
Sci. Aging Knowl. Environ., June 28, 2004; 2004(25): pe27 - pe27.
[Abstract] [Full Text]


Home page
Mol. Biol. CellHome page
J. F. Morley and R. I. Morimoto
Regulation of Longevity in Caenorhabditis elegans by Heat Shock Factor and Molecular Chaperones
Mol. Biol. Cell, February 1, 2004; 15(2): 657 - 664.
[Abstract] [Full Text] [PDF]


Home page
SCI AGING KNOWL ENVIRONHome page
M. Leslie
Stress for Success
Sci. Aging Knowl. Environ., February 12, 2003; 2003(6): ns1 - 1.
[Abstract] [Full Text] [PDF]


Home page
Physiol. GenomicsHome page
M. Treinin, J. Shliar, H. Jiang, J. A. Powell-Coffman, Z. Bromberg, and M. Horowitz
HIF-1 is required for heat acclimation in the nematode Caenorhabditis elegans
Physiol Genomics, June 24, 2003; 14(1): 17 - 24.
[Abstract] [Full Text] [PDF]


Home page
J Gerontol A Biol Sci Med SciHome page
J. E. Morley
Editorial: Hot Topics in Geriatrics
J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2003; 58(1): M30 - 36.
[Full Text] [PDF]


Home page
GeneticsHome page
D. Garigan, A.-L. Hsu, A. G. Fraser, R. S. Kamath, J. Ahringer, and C. Kenyon
Genetic Analysis of Tissue Aging in Caenorhabditis elegans: A Role for Heat-Shock Factor and Bacterial Proliferation
Genetics, July 1, 2002; 161(3): 1101 - 1112.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
All GSA journals The Gerontologist
Journals of Gerontology Series B: Psychological Sciences and Social Sciences
Copyright © 2002 by The Gerontological Society of America.