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a Departments of Internal Medicine "D, "
b Ophthalmology, Tel Aviv Sourasky Medical Center, Israel, affiliated with the Sackler Faculty of Medicine
c Neurology, Tel Aviv Sourasky Medical Center, Israel, affiliated with the Sackler Faculty of Medicine
d Gastroenterology, Tel Aviv Sourasky Medical Center, Israel, affiliated with the Sackler Faculty of Medicine
e Department of Histology and Cell Biology, Sackler Faculty of Medicine, Tel Aviv University, Israel
f Department of Geriatrics, Shaare Zedek Medical Center, Jerusalem, Israel
g Timorim Technologies, Jerusalem, Israel
Shlomo Berliner, Department of Internal Medicine "D," Tel-Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239 Israel E-mail: shapiraiz{at}tasmc.health.gov.il.
Background. Medical personnel who work in small geriatric institutions most frequently do not have access to realtime laboratory facilities.
Methods. In order to present a new method to determine the presence of an inflammatory response and for the assessment of its intensity, 118 patients aged 77 ± 6 years with various bacterial infections were evaluated as well as 129 elderly individuals with various stressful conditions but no acute infections who served as controls. The leukocyte and erythrocyte adhesiveness/aggregation tests were performed by using a simple slide test and image analysis. The availability of the CD11b/CD18 and CD62L antigen on the leukocytes' surface was measured by whole blood flow cytometry, and the quantitative C-reactive protein by using laser nephelometry and specific antihuman C-reactive protein antibodies.
Results. A significant difference was noted between patients and controls for all variables obtained by the slide test and image analysis. In addition, a highly significant correlation was noted between the number of leukocytes counted on the slides and white blood cell count, between the leukocyte adhesiveness/aggregation test and quantitative C-reactive protein, and between the degree of erythrocyte adhesiveness/aggregation and either the Westergren sedimentation or fibrinogen concentration.
Conclusions. By using our low-cost and real-time slide test, any medical or paramedical personnel can get relevant information regarding the presence of an acute phase response at the point of care.
This article has been cited by other articles: (Search Google Scholar for Other Citing Articles)
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  O. Rogowski, I. Shapira, S. Berliner, J. Serov, P. Halpern, D. Zeltser, B. Rudensky, and T. Dwolatzky Acute Phase Response Detection and Quantitation at the Point of Care in Older Adults With Acute Bacterial Infections J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2005; 60(10): 1324 - 1327. [Abstract] [Full Text] [PDF]
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 D Zeltser, O Rogowski, S Berliner, T Mardi, D Justo, J Serov, M Rozenblat, D Avitzour, and I Shapira Sex differences in the expression of haemorheological determinants in individuals with atherothrombotic risk factors and in apparently healthy people Heart, March 1, 2004; 90(3): 277 - 281. [Abstract] [Full Text] [PDF]
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J. E. Morley Editorial: Hot Topics in Geriatrics J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2003; 58(1): M30 - 36. [Full Text] [PDF]
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| All GSA journals | The Gerontologist |
| Journals of Gerontology Series B: Psychological Sciences and Social Sciences | |
