Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]
Author:
 		Keyword(s):
Year:  Vol:  Page: 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Cited by other online articles
Google Scholar
Right arrow Articles by Korosi, J.
Right arrow Articles by Meneilly, G. S.
Right arrow Articles citing this Article
PubMed
Right arrow PubMed Citation
Right arrow Articles by Korosi, J.
Right arrow Articles by Meneilly, G. S.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 56:M575-M579 (2001)
© 2001 The Gerontological Society of America

Effect of Aging and Diabetes on the Enteroinsular Axis

Judit Korosia, Christopher H.S. McIntoshb, Raymond A. Pedersonb, Hans-Ulrich Demuthc, Joel F. Habenerd, Ronald Gingeriche, Josephine M. Eganf, Dariush Elahid and Graydon S. Meneillya

a Departments of Medicine, University of British Columbia, Vancouver, Canada
b Departments of Physiology, University of British Columbia, Vancouver, Canada
c Hans Kneoll Institute for Natural Product Research, Halle, Germany
d Department of Medicine, Harvard University, Boston, Massachusetts
e Linco Research Inc., St. Charles, Missouri
f Laboratory of Clinical Physiology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland

Graydon S. Meneilly, Rm S 169, Vancouver Hospital and Health Sciences Centre, UBC Site 2211, Wesbrook Mall, Vancouver, BC V6T 2B5 E-mail: meneilly{at}interchange.ubc.ca.

Decision Editor: John E. Morley, MB, BCh

Background. The current studies were designed to examine the effect of aging and diabetes on the enteroinsular axis.

Methods. Healthy young control subjects (n = 10 young; age 23 ± 1 years; body mass index [BMI] 24 ± 1 kg/m2), healthy elderly subjects (n = 10; age 80 ± 2 years; BMI 26 ± 1 kg/m2), and elderly patients with type 2 diabetes (n = 10; age 76 ± 2 years; BMI 26 ± 2 kg/m2) underwent a 3-hour oral glucose tolerance test (glucose dose 40 gm/m2).

Results. Insulin responses were not different between young controls and elderly patients with diabetes but were significantly lower in elderly patients with diabetes and young controls than in elderly controls (young control: 178 ± 27 pM; elderly control: 355 ± 57 pM; elderly diabetes: 177 ± 30 pM; p < .05 elderly control vs young control and elderly diabetes). Total glucagon-like peptide 1 (GLP-1) responses were not significantly different between young and elderly controls and patients with diabetes (young control: 15 ± 2 pM; old control: 8 ± 2 pM; elderly diabetes: 12 ± 3 pM; p = ns). Active GLP-1 responses were also not different between young and elderly controls and patients with diabetes (young control: 5 ± 1 pM; old control: 6 ± 1 pM; elderly diabetes: 7 ± 1 pM; p = ns). However, the difference between total and active GLP levels was significantly greater in the young controls (young control: 10 ± 2 pM; old control: 2 ± 2 pM; elderly diabetes: 4 ± 2 pM; p < .05, young vs elderly). Glucose-dependent insulinotropic polypeptide responses were not different between young and elderly controls and between elderly controls and patients with diabetes but were significantly higher in elderly patients with diabetes than in young controls (young control: 97 ± 12 pM; elderly control: 121 ± 16 pM; elderly diabetes: 173 ± 27 pM; p < .05, young vs elderly diabetes). Glucagon responses were reduced in elderly controls but were similar in young controls and elderly patients with diabetes (young control: 15 ± 1 pM; elderly control: 9 ± 1 pM; elderly diabetes: 16 ± 1 pM; p < .01 elderly control vs young control and elderly diabetes). Dipeptidyl peptidase IV levels were lower in both elderly controls and patients with diabetes when compared with young controls (young control: 0.17 ± 0.01; elderly control: 0.15 ± 0.01; elderly diabetes: 0.15 ± 0.01 {Delta}OD/20 minutes; p < .05, elderly vs young).

Conclusions. We conclude that normal aging and diabetes are associated with multiple changes in the enteroinsular axis.




This article has been cited by other articles: (Search Google Scholar for Other Citing Articles)


Home page
 J Gerontol A Biol Sci Med SciHome page
D. O'Donovan, C. Feinle-Bisset, C. Chong, A. Cameron, A. Tonkin, J. Wishart, M. Horowitz, and K. L. Jones
Intraduodenal Guar Attenuates the Fall in Blood Pressure Induced by Glucose in Healthy Older Adults
J. Gerontol. A Biol. Sci. Med. Sci., June 1, 2005; 60(7): 940 - 946.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol.Home page
A. M. Chang and J. B. Halter
Aging and insulin secretion
Am J Physiol Endocrinol Metab, January 1, 2003; 284(1): E7 - 12.
[Abstract] [Full Text] [PDF]

Home page
 J Gerontol A Biol Sci Med SciHome page
G. S. Meneilly, C. H.S. McIntosh, R. A. Pederson, J. F. Habener, R. Gingerich, J. M. Egan, and D. Elahi
Glucagon-like Peptide-1 (7-37) Augments Insulin-Mediated Glucose Uptake in Elderly Patients With Diabetes
J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2001; 56(11): M681 - 685.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
All GSA journals The Gerontologist
Journals of Gerontology Series B: Psychological Sciences and Social Sciences
Copyright © 2001 by The Gerontological Society of America.