Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]
Author:
 		Keyword(s):
Year:  Vol:  Page: 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Cited by other online articles
Google Scholar
Right arrow Articles by McNeal, M. G.
Right arrow Articles by Payami, H.
Right arrow Articles citing this Article
PubMed
Right arrow PubMed Citation
Right arrow Articles by McNeal, M. G.
Right arrow Articles by Payami, H.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 56:B294-B301 (2001)
© 2001 The Gerontological Society of America

Predictors of Healthy Brain Aging

Melissa Gonzales McNeala, Sepideh Zareparsib, Richard Camiciolib, Alison Dameb, Diane Howiesonb, Joseph Quinnb,d, Melvyn Ballb,c, Jeffrey Kayeb,d and Haydeh Payamib

a Departments of Molecular and Medical Genetics, Oregon Health Sciences University, Portland
b Departments of Neurology, Oregon Health Sciences University, Portland
c Departments of Pathology, Oregon Health Sciences University, Portland
d Portland Veteran's Affairs Medical Center, Oregon

Haydeh Payami, Department of Neurology, CR131, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97201 E-mail: payamih{at}ohsu.edu.

Decision Editor: John Faulkner, PhD

To determine if superior health at old age protects against cognitive impairment (CI) and Alzheimer's disease (AD), we prospectively studied 100 optimally healthy oldest-old (>=85 years) individuals. Initially, subjects represented the top 3% of the oldest old for health. During 5.6 ± 0.3 years of follow-up, 34 subjects developed CI, and 23 progressed to AD. By age 100, probability of CI and AD were .65 ± .09 and .49 ± .10. Median onset age was 97 years for CI and 100 for AD. Clearly, superior health at old age does not guarantee protection against cognitive decline. Lifetime risks were similar to the general population but onset ages were later, suggesting factors that delay onset are key to improving cognitive health in the elderly. In this population, absence of apolipoprotein E-{epsilon}4 and male gender were associated with delayed onset, whereas estrogen use and education had no detectable effect on cognitive outcome.




This article has been cited by other articles: (Search Google Scholar for Other Citing Articles)


Home page
 NeurologyHome page
L.C. Silbert, J.F. Quinn, M.M. Moore, E. Corbridge, M.J. Ball, G. Murdoch, G. Sexton, and J.A. Kaye
Changes in premorbid brain volume predict Alzheimer's disease pathology
Neurology, August 26, 2003; 61(4): 487 - 492.
[Abstract] [Full Text] [PDF]

Home page
 J Gerontol A Biol Sci Med SciHome page
J. E. Morley
The Need for a Men's Health Initiative
J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2003; 58(7): M614 - 617.
[Full Text] [PDF]

Home page
 J Gerontol A Biol Sci Med SciHome page
J. E. Morley and H. M. Perry III
Androgens and Women at the Menopause and Beyond
J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2003; 58(5): M409 - 416.
[Full Text] [PDF]

Home page
 J Gerontol A Biol Sci Med SciHome page
S. Asthana
Estrogen and Cognition: The Story So Far
J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2003; 58(4): M322 - 323.
[Full Text] [PDF]

Home page
 J Gerontol A Biol Sci Med SciHome page
W. A. Banks and J. E. Morley
Memories Are Made of This: Recent Advances in Understanding Cognitive Impairments and Dementia
J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2003; 58(4): M314 - 321.
[Full Text] [PDF]

Home page
 J Gerontol A Biol Sci Med SciHome page
J. E. Morley
Editorial: Hot Topics in Geriatrics
J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2003; 58(1): M30 - 36.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
All GSA journals The Gerontologist
Journals of Gerontology Series B: Psychological Sciences and Social Sciences
Copyright © 2001 by The Gerontological Society of America.