|
|
||||||||
a Departments of Geriatric Medicine, Laboratories of
b Departments of Clinical Neurophysiology, Laboratories of
c Departments of Medical Statistics, Laboratories of
d Pediatrics and Neurology, University Medical Centre Nijmegen, The Netherlands
e Neurology, University Medical Centre Nijmegen, The Netherlands
Dieneke Z. van Asselt, Department of Geriatric Medicine, University Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands E-mail: D.vanAsselt{at}czzoger.azn.nl.
Decision Editor: John E. Morley, MB, BCh
Background. Mild cobalamin (Cbl) deficiency is frequently found in older persons and is associated with cognitive and cerebral abnormalities. The effects of Cbl supplementation on these abnormalities are largely unknown.
Methods. In a single-blind, placebo-controlled intervention study, 16 healthy community-dwelling elderly subjects with low plasma Cbl concentration and no cognitive impairments were studied. Subjects underwent 1 month of treatment with placebo, followed by 5 months of treatment with intramuscular injections of hydroxycobalamin. Before and after measurements of plasma cobalamin, total homocysteine (tHcy), methylmalonic acid (MMA), quantitative electroencephalograph (qEEG), and psychometric tests were taken.
Results. After Cbl supplementation, plasma Cbl concentrations increased, and plasma MMA and tHcy concentrations decreased. The performance on the Verbal Word Learning Test, Verbal Fluency and Similarities improved. qEEG showed more fast activity and less slow activity. Lower plasma tHcy concentrations were related to increased fast activity on qEEG on the one hand and improved performance on the Verbal Word Learning Test and Similarities on the other. Increased fast or decreased slow activity on qEEG was associated with improved performance on the Verbal Word Learning Test, Similarities and Verbal Fluency.
Conclusions. Electrographic signs of improved cerebral function and improved cognitive function were found after Cbl supplementation in older subjects with low plasma Cbl concentrations who were free of significant cognitive impairment. These improvements were related to a reduction of plasma tHcy concentration.
This article has been cited by other articles: (Search Google Scholar for Other Citing Articles)
|
S. J Eussen, L. C de Groot, L. W Joosten, R. J Bloo, R. Clarke, P. M Ueland, J. Schneede, H. J Blom, W. H Hoefnagels, and W. A van Staveren Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial Am. J. Clinical Nutrition, August 1, 2006; 84(2): 361 - 370. [Abstract] [Full Text] [PDF] |
||||
|
S. P Mooijaart, J. Gussekloo, M. Frolich, J. Jolles, D. J Stott, R. G. Westendorp, and A. J. de Craen Homocysteine, vitamin B-12, and folic acid and the risk of cognitive decline in old age: the Leiden 85-Plus Study Am. J. Clinical Nutrition, October 1, 2005; 82(4): 866 - 871. [Abstract] [Full Text] [PDF] |
||||
|
S. J. P. M. Eussen, L. C. P. G. M. de Groot, R. Clarke, J. Schneede, P. M. Ueland, W. H. L. Hoefnagels, and W. A. van Staveren Oral Cyanocobalamin Supplementation in Older People With Vitamin B12 Deficiency: A Dose-Finding Trial Archives of Internal Medicine, May 23, 2005; 165(10): 1167 - 1172. [Abstract] [Full Text] [PDF] |
||||
|
C. Lewerin, M. Matousek, G. Steen, B. Johansson, B. Steen, and H. Nilsson-Ehle Significant correlations of plasma homocysteine and serum methylmalonic acid with movement and cognitive performance in elderly subjects but no improvement from short-term vitamin therapy: a placebo-controlled randomized study Am. J. Clinical Nutrition, May 1, 2005; 81(5): 1155 - 1162. [Abstract] [Full Text] [PDF] |
||||
|
H. Refsum, A. D. Smith, P. M. Ueland, E. Nexo, R. Clarke, J. McPartlin, C. Johnston, F. Engbaek, J. Schneede, C. McPartlin, and J. M. Scott Facts and Recommendations about Total Homocysteine Determinations: An Expert Opinion Clin. Chem., January 1, 2004; 50(1): 3 - 32. [Abstract] [Full Text] [PDF] |
||||
|
S. P Stabler Vitamins, homocysteine, and cognition Am. J. Clinical Nutrition, September 1, 2003; 78(3): 359 - 360. [Full Text] [PDF] |
||||
|
W. A. Banks and J. E. Morley Memories Are Made of This: Recent Advances in Understanding Cognitive Impairments and Dementia J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2003; 58(4): M314 - 321. [Full Text] [PDF] |
||||
|
J. E. Morley Editorial: Hot Topics in Geriatrics J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2003; 58(1): M30 - 36. [Full Text] [PDF] |
||||
HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
---|
All GSA journals | The Gerontologist |
Journals of Gerontology Series B: Psychological Sciences and Social Sciences |