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Fiber-Type Transitions and Satellite Cell Activation in Low-Frequency-Stimulated Muscles of Young and Aging Rats

Charles T. Putman^a, Karim R. Sultan^b, Thomas Wassmer^b, Jeremy A. Bamford^a, Dejan korjanc^b and Dirk Pette^b

^a Skeletal Muscle Research Group, Faculty of Physical Education, University of Alberta, Edmonton, Canada
^b Department of Biology, University of Konstanz, Germany

Charles T. Putman, Assistant Professor, AHFMR Medical Scholar, E-417 Van Vliet Centre, University of Alberta, Edmonton, Alberta, Canada, T6G 2H9 E-mail: tputman{at}ualberta.ca.

Decision Editor: John A. Faulkner, PhD

We examined satellite cell content and the activity of satellite cell progeny in tibialis anterior muscles of young (15 weeks) and aging (101 weeks) Brown Norway (BN) rats, after they were exposed for 50 days to a standardized and highly reproducible regime of chronic low-frequency electrical stimulation. Chronic low-frequency electrical stimulation was successful in inducing fast-to-slow fiber-type transformation, characterized by a 2.3-fold increase in the proportion of IIA fibers and fourfold and sevenfold decreases in the proportion of IID/X and IIB fibers in both young and aging BN rats. These changes were accompanied by a twofold increase in the satellite cell content in both the young and aging groups; satellite cell content reached a level that was significantly higher in the young group (p < .04). The total muscle precursor cell content (i.e., satellite cells plus progeny), however, did not differ between groups, because there was a greater number of satellite cell progeny passing through the proliferative and differentiative compartments of the aging group. The resulting 1.5-fold increase in myonuclear content was similar in the young and aging groups. We conclude that satellite cells and satellite cell progeny of aging BN rats possess an unaltered capacity to contribute to the adaptive response.

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