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Effects of Chronic Food Restriction and Exercise Training on the Recovery of Cardiac Function Following Ischemia

^a Department of Physiology, Midwestern University, Glendale, Arizona
^b Ocean Sciences Centre, St. John's Campus Memorial University of Newfoundland, St. John's
^c Department of Biology and Biochemistry, Mount Allison University, Sackville, New Brunswick
^d Department of Psychology, Mount Allison University, Sackville, New Brunswick

Tom L. Broderick, Department of Physiology, Midwestern University, 19555 North 59th Avenue, Glendale, AZ 85308 E-mail: tbrode{at}arizona.midwestern.edu.

Decision Editor: Jay Roberts, PhD

Clinical and experimental data suggest that exercise training (ET) and food restriction (FR) improve cardiovascular function. However, the effects of long-term FR or FR in combination with ET on the recovery of cardiac function following ischemia have not been determined. Male Wistar rats were assigned to ad libitum-fed, FR, ad libitum-exercise, and FR–exercise groups. Mechanical function of isolated working hearts was assessed in response to increases in afterload resistance and following global no-flow ischemia. At low workload, there was a significant FR effect on aortic flow as well as an interaction between FR and ET on systolic pressure. These effects remained when hearts were subjected to increases in aortic afterload resistance. During reperfusion of ischemic hearts, there was a significant FR effect on aortic flow and systolic pressure and a significant ET effect on diastolic pressure. An interaction between FR and ET on heart rate was also seen during reperfusion. In terms of percent recovery of heart function following ischemia, FR continued to affect aortic flow, and we observed an interaction between FR and ET on aortic flow. Our results clearly indicate that the myocardium from the FR animal or the FR, exercise-trained rat is more resistant to ischemia.