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Locomotor Activity in Female Rhesus Monkeys

Assessment of Age and Calorie Restriction Effects

^a R.O.W. Sciences, Gaithersburg, Maryland, and National Institutes of Health Animal Center, Poolesville, Maryland
^b Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland
^c Office of Research Services, Veterinary Resources Program, National Institutes of Health, Bethesda, Maryland

Donald K. Ingram, Gerontology Research Center, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224 E-mail: doni{at}vax.grc.nia.nih.gov.

Decision Editor: Jay Roberts, PhD

As a component of a long-term, longitudinal study of aging in this primate model, the objective of the current experiment was to assess age and diet effects on locomotor activity in a cross-sectional analysis. By attaching a motion detection device to the home cage, locomotor activity was monitored over a week in a group of female rhesus monkeys (Macaca mulatta) 6–26 yrs of age. About half these monkeys composed a control group fed a nutritionally fortified diet near ad libitum levels, whereas an experimental group had been fed the same diet at levels 30% less than comparable control levels for approximately 5 yrs prior to testing. Among control monkeys, a marked age-related decline in activity was noted when total activity was considered and also when diurnal and nocturnal periods of activity were analyzed separately. When comparing activity levels between control and experimental groups, only one significant diet effect was noted, which was in the youngest group of monkeys (6–8 yrs of age) during the diurnal period. Monkeys in the experimental group exhibited reduced activity compared to controls. Body weight was not consistently correlated to activity levels. In some older groups, heavier monkeys tended to show greater activity, but in younger groups the opposite pattern was observed.

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				G. S. Roth, J. A. Mattison, M. A. Ottinger, M. E. Chachich, M. A. Lane, and D. K. Ingram Aging in Rhesus Monkeys: Relevance to Human Health Interventions Science, September 3, 2004; 305(5689): 1423 - 1426. [Abstract] [Full Text] [PDF]