HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Cited by other online articles Google Scholar Articles by Goldberg, A. P. Articles by Hagberg, J. M. Articles citing this Article PubMed PubMed Citation Articles by Goldberg, A. P. Articles by Hagberg, J. M.

Cardiovascular Fitness, Body Composition, and Lipoprotein Lipid Metabolism in Older Men

^a Division of Gerontology, Department of Medicine, University of Maryland School of Medicine
^b Geriatrics Service/GRECC, Baltimore Veterans Administration Maryland Health Care System
^c Division of Gerontology and Geriatrics, Department of Medicine, Johns Hopkins University School of Medicine, Bayview Medical Center, Baltimore, Maryland.
^d Ernest Orlando Lawrence Berkeley National Laboratory, University of California, Berkeley
^e Center on Aging, University of Maryland, College Park

Andrew P. Goldberg, GRECC (BT/18/GR), Baltimore VA Medical Center, 10 N. Greene St., Baltimore, MD 21201 E-mail: apgoldbe{at}umaryland.edu.

Decision Editor: William B. Ershler, MD

Background. Lipoprotein lipids in older individuals are affected by family history of coronary artery disease (CAD), obesity, diet, and physical activity habits.

Methods. The relationship of obesity and physical fitness (O₂max) to lipoprotein lipids and postheparin lipases was examined in a cross-sectional study of 12 lean (LS) and 26 obese (OS) sedentary men and 18 master athletes (MAs) aged 65 ± 1 years (mean ± SE). The men were healthy, had no family history of CAD, and were weight stable on AHA diets at the time of study.

Results. O₂max was similar in LS and OS men but higher in the MAs. The OS men had a higher percentage of body fat (%BF), waist circumference, and waist:hip ratio (WHR) than the MA and LS men, but MA and LS men differed only in waist circumference. Total and LDL-C levels were comparable, but HDL-C, HDL₂-C, and %HDL_2b subspecies were higher in MAs than in OS and LS men, and in LS than in OS men. Triglyceride (TG) was similar in MAs and LS men but higher in OS men. Across groups, two multiple regression analyses models (O₂max, %BF, and WHR or waist circumference) showed that %BF and O₂max independently predicted HDL-C and HDL₂, whereas WHR predicted TG more strongly than waist circumference Postheparin lipoprotein lipase activity (LPL) was comparable among groups and correlated independently with O₂max. Total postheparin lipolytic activity (PHLA), hepatic lipase activity (HL), and HL:PHLA ratio were similar in MAs and LS men but higher in OS men. In both multiple regression analysis models, only %BF predicted HL activity and the HL:PHLA ratio. The HL:PHLA ratio independently predicted HDL-C, HDL₂-C, %HDL_2b, %HDL₃ subspecies, and the cholesterol:HDL-C ratio, whereas LPL activity predicted TG.

Conclusions. Increased fitness and reduced total and abdominal fatness in MAs are associated with lower HL and higher LPL activities, which may mediate their higher HDL-C and lower TG levels relative to their sedentary peers.

This article has been cited by other articles: (Search Google Scholar for Other Citing Articles)

				N. Yi, S. Chiu, D. B. Allison, J. S. Fisler, and C. H. Warden Epistatic interaction between two nonstructural loci on chromosomes 7 and 3 influences hepatic lipase activity in BSB mice J. Lipid Res., November 1, 2004; 45(11): 2063 - 2070. [Abstract] [Full Text] [PDF]

				S. Chiu, J. S. Fisler, G. M. Espinal, P. J. Havel, J. S. Stern, and C. H. Warden The Yellow Agouti Mutation Alters Some But Not All Responses to Diet and Exercise Obesity, August 1, 2004; 12(8): 1243 - 1255. [Abstract] [Full Text] [PDF]

				P. Farahani, J. S. Fisler, H. Wong, A. L. Diament, N. Yi, and C. H. Warden Reciprocal Hemizygosity Analysis of Mouse Hepatic Lipase Reveals Influence on Obesity Obesity, February 1, 2004; 12(2): 292 - 305. [Abstract] [Full Text] [PDF]

				S. K Fried and S. P Rao Sugars, hypertriglyceridemia, and cardiovascular disease Am. J. Clinical Nutrition, October 1, 2003; 78(4): 873S - 880. [Abstract] [Full Text] [PDF]

				F. R. Sattler, E. T. Schroeder, M. P. Dube, S. V. Jaque, C. Martinez, P. J. Blanche, S. Azen, and R. M. Krauss Metabolic effects of nandrolone decanoate and resistance training in men with HIV Am J Physiol Endocrinol Metab, December 1, 2002; 283(6): E1214 - 1222. [Abstract] [Full Text] [PDF]

				R. A. Wiswell, S. A. Hawkins, S. V. Jaque, D. Hyslop, N. Constantino, K. Tarpenning, T. Marcell, and E. T. Schroeder Relationship Between Physiological Loss, Performance Decrement, and Age in Master Athletes J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2001; 56(10): M618 - 626. [Abstract] [Full Text] [PDF]