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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 55:B228-B232 (2000)
© 2000 The Gerontological Society of America

Minireview

Mechanisms by Which the Metabolic Syndrome and Diabetes Impair Memory

Meena Kumaria, Eric Brunnera and Rebecca Fuhrera

a International Centre for Health and Society, Department of Epidemiology and Public Health, Royal Free and University College Medical School, London.

Meena Kumari, International Centre for Health and Society, Department of Epidemiology and Public Health, Royal Free and University College Medical School, London, WC1 6BT, UK E-mail: m.kumari{at}public-health.ucl.ac.uk.

Decision Editor: Jay Roberts, PhD

Type 2 diabetes is associated with an increased risk of cognitive dysfunction. These effects seem particularly true for memory functions. This article examines how diabetes and the biological changes that occur with diabetes such as hyperglycemia, changes in insulin concentration, hypertension, and changes in lipid levels might lead to these alterations in cognitive functioning, with an emphasis on the mechanisms leading to changes in memory.




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