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Use of Muscle Functional Magnetic Resonance Imaging With Older Individuals

^a Department of Exercise Science, Syracuse University, New York
^b Department of Radiology, State University of New York Upstate Medical University, Syracuse

Lori L. Ploutz-Snyder, Exercise Science, Room 201, Women\|[apos ]\|s Building, Syracuse University, Syracuse, NY 13244 E-mail: llploutz{at}syr.edu.

Decision Editor: Jay Roberts, PhD

Muscle functional magnetic resonance imaging (mfMRI) has been widely used to study muscle recruitment in exercise in young healthy subjects, but has not been validated or used with older subjects. This study validates and demonstrates the use of mfMRI in older subjects. Subjects consisted of apparently healthy sedentary younger (n = 7) and older (n = 6) women. Proton transverse relaxation (T2)-weighted MRI scans were obtained of the quadriceps femoris at rest and immediately following three bouts of knee extension exercise (50%, 75%, and 100% of untrained 5 x 10 repetition maximum [RM]). Older subjects performed knee extension training for 12 weeks and repeated the MRI scan protocol using the same absolute loads. Training induced a 13% increase in 1 RM and a 25% increase in 5 x 10 RM. Older subjects had higher resting T2 values compared with younger subjects; however, the T2 response to exercise (slope) was similar among groups (young = 0.063 ± 0.003, older untrained = 0.055 ± 0.011, older trained = 0.053 ± 0.008; p > .05). In all cases, T2 increased linearly with load. Trained older subjects showed a lower T2 response when lifting the same absolute load compared with before training, which is consistent with results previously obtained from young subjects. In the older population, mfMRI is appropriate for use and offers benefits over other technologies.

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				L.L. Ploutz-Snyder, E.L. Giamis, M. Formikell, and A.E. Rosenbaum Resistance Training Reduces Susceptibility to Eccentric Exercise-Induced Muscle Dysfunction in Older Women J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2001; 56(9): B384 - 390. [Abstract] [Full Text] [PDF]