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Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Vol 53, Issue 1 B19-B24, Copyright © 1998 by The Gerontological Society of America
JOURNAL ARTICLE |
DH Han, PA Hansen, MM Chen and JO Holloszy
Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
The purpose of this study was to determine whether administration of dehydroepiandrosterone (DHEA) protects male rats against the accumulation of body fat the development of insulin resistance with advancing age. We found that supplementation of the diet with 0.3% DHEA between the ages of 5 months and approximately 25 months resulted in a significantly lower final body weight (DHEA, 593 +/- 18 g vs control, 668 +/- 12 g, p < 0.02), despite no decrease in food intake. Lean body mass was unaffected by the DHEA, and the lower body weight was due to a approximately 25% reduction in body fat. The rate of glucose disposal during a euglycemic, hyperinsulinemic clamp was 30% higher in the DHEA group than in the sedentary controls due to a greater insulin responsiveness. The DHEA administration was as effective in reducing body fat content and maintaining insulin responsiveness as exercise in the form of voluntary wheel running. The DHEA had no significant effect on muscle GLUT4 content. A preliminary experiment provided evidence suggesting that muscle insulin signaling, as reflected in binding of phosphatidylinositol 3-kinase to the insulin receptor substrate-1, was enhanced in the DHEA-treated and wheel running groups as compared to controls. These results provide evidence that DHEA, like exercise, protects against excess fat accumulation and development of insulin resistance in rats.
This article has been cited by other articles: (Search Google Scholar for Other Citing Articles)
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  D. T. Villareal and J. O. Holloszy Effect of DHEA on Abdominal Fat and Insulin Action in Elderly Women and Men: A Randomized Controlled Trial JAMA, November 10, 2004; 292(18): 2243 - 2248. [Abstract] [Full Text] [PDF]
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 C. Lemieux, F. Picard, F. Labrie, D. Richard, and Y. Deshaies The Estrogen Antagonist EM-652 and Dehydroepiandrosterone Prevent Diet- and Ovariectomy-Induced Obesity Obes. Res., March 1, 2003; 11(3): 477 - 490. [Abstract] [Full Text] [PDF]
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 E. B. Arias, L. E. Gosselin, and G. D. Cartee Exercise Training Eliminates Age-Related Differences in Skeletal Muscle Insulin Receptor and IRS-1 Abundance in Rats J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2001; 56(10): B449 - 455. [Abstract] [Full Text] [PDF]
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