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Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Vol 52, Issue 5 B277-B284, Copyright © 1997 by The Gerontological Society of America
JOURNAL ARTICLE |
DR Sell and VM Monnier
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio, USA. [email protected]
In recent years, there has been a growing interest in the development of a panel of biomarkers useful in the evaluation of interventions on aging processes. An ideal marker should change with age, be related to species longevity, and respond to the effects of dietary restriction, which is the only intervention currently known to increase species longevity. In the present study; we compared parameters of collagen aging (i.e., tail tendon break time [TBT] and the glycoxidation product pentosidine) in tendon, ear, and skin of two species of rodents with different life spans: the shorter-lived DBA/2 versus the longer-lived C57BL/6 mouse strain. Both TBT and tissue pentosidine significantly increased with age in both strains of mice. The rate of increase for TBT And pentosidine occurred faster for the DBA/2 compared with the C57BL/6 strain. Dietary restriction significantly inhibited the age- related increase of TBT and pentosidine formation rte in DBA/2 mice. In C57BL/6 mice, the age-related increase of TBT was significantly inhibited by dietary restriction. However, except for tendon at 24 months, pentosidine level was not affected by dietary restriction. These studies show that the rate of collagen aging, as reflected by TBT and glycoxidation, increases proportionally with age, and that these rate increases are related to longevity in two strains of mice. Pentosidine can be monitored with age just as well in a piece of easily accessible ear tissue as in skin or tendon. Thus, pentosidine is expected to be a useful and easily measurable noninvasive marker in future intervention studies on aging.
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  H. Van Remmen, Y. Ikeno, M. Hamilton, M. Pahlavani, N. Wolf, S. R. Thorpe, N. L. Alderson, J. W. Baynes, C. J. Epstein, T.-T. Huang, J. Nelson, R. Strong, and A. Richardson Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging Physiol Genomics, December 16, 2003; 16(1): 29 - 37. [Abstract] [Full Text] [PDF]
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 D. R. Sell, J. F. Nelson, and V. M. Monnier Effect of Chronic Aminoguanidine Treatment on Age-Related Glycation, Glycoxidation, and Collagen Cross-linking in the Fischer 344 Rat J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2001; 56(9): B405 - 411. [Abstract] [Full Text] [PDF]
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 D. R. SELL, N. R. KLEINMAN, and V. M. MONNIER Longitudinal determination of skin collagen glycation and glycoxidation rates predicts early death in C57BL/6NNIA mice FASEB J, January 1, 2000; 14(1): 145 - 156. [Abstract] [Full Text]
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