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Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Vol 52, Issue 2 B111-B117, Copyright © 1997 by The Gerontological Society of America
JOURNAL ARTICLE |
P Mohanakrishnan, AH Fowler, JP Vonsattel, PR Jolles, MM Husain, P Liem, L Myers and RA Komoroski
Department of Radiology, University of Arkansas for Medical Sciences, Little Rock.
The concentrations of selected metabolites in the hippocampus and cerebellum of 13 Alzheimer's diseased (AD) and four nondemented postmortem brains were measured using high resolution 1H NMR spectroscopy. For both the hippocampal region and the cerebellum, the putative neuronal marker N-acetyl aspartate (NAA) was significantly lower in AD brains relative to the nondemented brains. For the hippocampal region, the NAA concentration correlated inversely with semiquantitative assessments of neuronal loss and neurofibrillary tangles. The gamma-aminobutyric acid levels in both hippocampus and cerebellum of an age- and a postmortem interval-matched subset of AD brains were lower than those of the controls. Because the cerebellum is generally thought to be unaffected by AD, the NAA decrease in the Alzheimer cerebellum may be due to lesions of either the Alzheimer or non-Alzheimer type in contralateral cerebrum.
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F. Jessen, W. Block, F. Traber, E. Keller, S. Flacke, A. Papassotiropoulos, R. Lamerichs, R. Heun, and H. H. Schild Proton MR spectroscopy detects a relative decrease of N-acetylaspartate in the medial temporal lobe of patients with AD Neurology, September 12, 2000; 55(5): 684 - 688. [Abstract] [Full Text] [PDF] |
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