| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|---|
|
|
|
|||||||
|
|||||||||
Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Vol 51, Issue 3 B208-B213, Copyright © 1996 by The Gerontological Society of America
JOURNAL ARTICLE |
DJ Dean and GD Cartee
Biodynamics Laboratory, University of Wisconsin, Madison, USA.
The primary purpose of this study was to determine the impact of brief dietary restriction (DR; 5 or 20 days) on skeletal muscle glucose transport activity (GTA) of 24-month-old female Fischer 344 rats. Basal GTA of isolated epitrochlearis muscles was unaffected by DR. Insulin- stimulated GTA was significantly increased by DR only at 20 days (51%). We also assessed the influence of DR on energy sources (blood-borne and stored). An approximately 20% decline in glycemia occurred in each DR group, but plasma-free fatty acid and beta-hydroxybutyrate concentrations were unaffected. Plasma insulin was reduced by 50% after 20 days. Hepatic glycogen was rapidly mobilized (-69% at 5 days; -83% at 20 days). The depletions of visceral adipose stores was slower (no significant decline at 5 days; -30% at 20 days), but the eventual reduction accounts for a significant amount of energy. The results demonstrate that muscle from old rats can rapidly upregulate GTA in response to brief DR. The relative magnitude of this increase represents a substantial portion of the increases previously observed after prolonged DR.
This article has been cited by other articles: (Search Google Scholar for Other Citing Articles)
|
|
 |
|
  C. E. McCurdy, R. T. Davidson, and G. D. Cartee Calorie restriction increases the ratio of phosphatidylinositol 3-kinase catalytic to regulatory subunits in rat skeletal muscle Am J Physiol Endocrinol Metab, May 1, 2005; 288(5): E996 - E1001. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. McCurdy, R. T. Davidson, and G. D. Cartee Brief calorie restriction increases Akt2 phosphorylation in insulin-stimulated rat skeletal muscle Am J Physiol Endocrinol Metab, October 1, 2003; 285(4): E693 - 700. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. P. Ferraris, Q.-X. Cao, and S. Prabhakaram Chronic but Not Acute Energy Restriction Increases Intestinal Nutrient Transport in Mice J. Nutr., March 1, 2001; 131(3): 779 - 786. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. C. Gazdag, T. J. Wetter, R. T. Davidson, K. A. Robinson, M. G. Buse, A. J. Yee, L. P. Turcotte, and G. D. Cartee Lower calorie intake enhances muscle insulin action and reduces hexosamine levels Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2000; 278(2): R504 - 512. [Abstract] [Full Text]
|
|
|
|
|
|
T. J. Wetter, A. C. Gazdag, D. J. Dean, and G. D. Cartee Effect of calorie restriction on in vivo glucose metabolism by individual tissues in rats Am J Physiol Endocrinol Metab, April 1, 1999; 276(4): E728 - 738. [Abstract] [Full Text]
|
|
|
|
|
|
J.-Y. Kim, L. A. Nolte, P. A. Hansen, D.-H. Han, K. Kawanaka, and J. O. Holloszy Insulin resistance of muscle glucose transport in male and female rats fed a high-sucrose diet Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1999; 276(3): R665 - 672. [Abstract] [Full Text]
|
|
|
|
|
|
D. J. Dean, J. T. Brozinick Jr., S. W. Cushman, and G. D. Cartee Calorie restriction increases cell surface GLUT-4 in insulin-stimulated skeletal muscle Am J Physiol Endocrinol Metab, December 1, 1998; 275(6): E957 - 964. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|---|
| All GSA journals | The Gerontologist |
| Journals of Gerontology Series B: Psychological Sciences and Social Sciences | |
