Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
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Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Vol 50, Issue 6 B378-B382, Copyright © 1995 by The Gerontological Society of America

JOURNAL ARTICLE

Immune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and nonsurvivors

FG Ferguson, A Wikby, P Maxson, J Olsson and B Johansson
Department of Veterinary Science, Pennsylvania State University, USA.

As a part of an ongoing longitudinal investigation, this study examined relationships between survival and selected immune system parameters in a sample (n = 102) of very old individuals (86-92 years at the time of initial immune system data collection). Analyses were performed comparing initial time-point measurements from those individuals who were alive (n = 75) and those who were deceased (n = 27) two years after initial data collection. Immune system measurements consisted of determination of peripheral blood lymphocytes and lymphocyte subsets, as well as T-cell responses to activation by Concanavalin A. Cluster analysis identified a subgroup associated with nonsurvival which indicated characteristics that included: poor T-cell proliferative responses, high CD8 percentages, and low CD4 and CD19 percentages. This multivariate analysis suggested that combinations of immune system parameters predict two-year survival otherwise not apparent when single immune system parameters were evaluated in the elderly.


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