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Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Vol 50, Issue 2 B79-B82, Copyright © 1995 by The Gerontological Society of America
JOURNAL ARTICLE |
S Klebanov, S Diais, WB Stavinoha, Y Suh and JF Nelson
Department of Physiology, University of Texas Health Science Center at San Antonio.
Food restriction (FR), which extends life span, is associated with an enhanced diurnal elevation of glucocorticoids. This increase in glucocorticoids may contribute to longevity by chronically enhancing the same protective mechanisms mobilized during acute stress. The objective of this study was to determine if attenuation of inflammation, a presumably protective effect of glucocorticoids, occurs in FR mice. Two-month-old male BALB/c mice were either fed ad lib (AL) or FR (60% AL calories) for 2 months. After one month, the diurnal elevation of plasma corticosterone was threefold higher in FR mice. Two weeks after corticosterone sampling, a hind foot pad of each mouse was injected with 20 microliters of 4% carrageenan. Maximum observed edema did not differ between FR and AL groups, but edema was reduced at onset and fell earlier in FR mice. Results indicate that at least one inflammatory reaction is attenuated by FR and are consistent with the hypothesis that FR enhances a potentially protective glucocorticoid activity.
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B. S. Baek, J. W. Kim, J. H. Lee, H. J. Kwon, N. D. Kim, H. S. Kang, M. A. Yoo, B. P. Yu, and H. Y. Chung Age-Related Increase of Brain Cyclooxygenase Activity and Dietary Modulation of Oxidative Status J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2001; 56(10): B426 - 431. [Abstract] [Full Text] [PDF]
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E.-S. Han, T. R. Evans, J. H. Shu, S. Lee, and J. F. Nelson Food Restriction Enhances Endogenous and Corticotropin-Induced Plasma Elevations of Free but Not Total Corticosterone Throughout Life in Rats J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2001; 56(9): B391 - 397. [Abstract] [Full Text] [PDF]
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 E.-S. Han, T. R. Evans, S. Lee, and J. F. Nelson Food Restriction Differentially Affects Pituitary Hormone mRNAs throughout the Adult Life Span of Male F344 Rats J. Nutr., June 1, 2001; 131(6): 1687 - 1693. [Abstract] [Full Text]
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 B. Chandrasekar, J. F. Nelson, J. T. Colston, and G. L. Freeman Calorie restriction attenuates inflammatory responses to myocardial ischemia-reperfusion injury Am J Physiol Heart Circ Physiol, May 1, 2001; 280(5): H2094 - 2102. [Abstract] [Full Text]
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E.-S. Han, T. R. Evans, and J. F. Nelson Adrenocortical Responsiveness to Adrenocorticotropic Hormone Is Enhanced in Chronically Food-Restricted Rats J. Nutr., September 1, 1998; 128(9): 1415 - 1420. [Abstract] [Full Text]
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