Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Vol 50, Issue 2 B72-B77, Copyright © 1995 by The Gerontological Society of America

JOURNAL ARTICLE

Anti-tumor action of dietary restriction is lesion-dependent in male Fischer 344 rats

Y Higami, BP Yu, I Shimokawa, H Bertrand, GB Hubbard and EJ Masoro
First Department of Pathology, Nagasaki University School of Medicine, Japan.

The effects of dietary restriction (DR) on spontaneous oncogenesis in male Fischer 344 rats were analyzed. Previously reported analyses of studies carried out in our laboratory demonstrated that DR reduces the incidence and delays the onset, but not the progression, of leukemia in male F344 rats. In this report, the influence of DR on pituitary tumors, adrenal pheochromocytoma, pancreatic islet cell tumors, and interstitial cell tumors of the testis was analyzed. DR reduced the relative incidence (relative onset rates) and delayed the onset of the four tumors. DR also retarded the progression (duration from onset to death) of pituitary tumors and pheochromocytoma. DR has delayed the onset of all tumors of the male F344 rat so far analyzed, but its effect on tumor progression appears to be lesion-dependent.

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