Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]
Author:
 		Keyword(s):
Year:  Vol:  Page: 

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Cited by other online articles
Google Scholar
Right arrow Articles by Gurdal, H.
Right arrow Articles by Johnson, M. D.
Right arrow Articles citing this Article
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gurdal, H.
Right arrow Articles by Johnson, M. D.

Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Vol 50, Issue 2 B67-B71, Copyright © 1995 by The Gerontological Society of America

JOURNAL ARTICLE

Effects of dietary restriction on the change in aortic alpha 1- adrenoceptor mediated responses during aging in Fischer 344 rats

H Gurdal, E Friedman and MD Johnson
Department of Pharmacology, Medical College of Pennsylvania, Philadelphia.

These studies examine changes in alpha 1-adrenoceptor-stimulated contraction, accumulation of inositol phosphates (IPs) and calcium influx during aging, and the effect of dietary restriction. The potency of norepinephrine (NE) at stimulating aortic contraction was highest in aortas from 1-month-old rats compared to 6- or 24-month-old rats, while the potency at stimulating IP accumulation was higher in 6- and 24- month-old rats. The fact that the NE potency for IP accumulation is not decreased with age and is even increased a little, indicates that PI hydrolysis is not limiting for contraction. The data from 24-month-old dietary restricted rats support the same idea. Dietary restriction greatly increased the potency of NE for IP accumulation in the old animals (by 20-fold), but did not restore potency for contraction. Nifedipine (1 microM), a calcium channel blocker, inhibited the NE- stimulated aortic contractile response by 28% in 1-month, 40% in 6- month, and 67% in 24-month-old rats. While nifedipine did not inhibit NE-stimulated IP accumulation in 1-month-old aortas, it inhibited by 30% in 6-month-old aortas and by 27% in 24-month-old aortas. Dietary restriction (DR) did influence the inhibitory effects of nifedipine. Nifedipine inhibition of NE-stimulated contraction in 24-month-old DR rats was comparable to the inhibition in 6-month-old ad libitum (ad lib) controls and was less than in 24-month-old controls. Furthermore, nifedipine was less effective at inhibiting NE-stimulated IP accumulation in aortas from 24-month-old DR rats compared to 24-month- old controls.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles: (Search Google Scholar for Other Citing Articles)


Home page
 J. Appl. Physiol.Home page
T. M. Seasholtz, G. Cai, H.-Y. Wang, and E. Friedman
Signal Transduction in Smooth Muscle: Selected Contribution: Effects of ischemia-reperfusion on vascular contractility and {alpha}1-adrenergic-receptor signaling in the rat tail artery
J Appl Physiol, August 1, 2001; 91(2): 1004 - 1010.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
E. Gao, D. L. Snyder, J. Roberts, E. Friedman, G. Cai, A. Pelleg, and J. Horwitz
Age-Related Decline in Beta Adrenergic and Adenosine A1 Receptor Function in the Heart Are Attenuated by Dietary Restriction
J. Pharmacol. Exp. Ther., April 1, 1998; 285(1): 186 - 192.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
All GSA journals The Gerontologist
Journals of Gerontology Series B: Psychological Sciences and Social Sciences
Copyright © 1995 by The Gerontological Society of America.