Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Vol 50, Issue 2 B59-B66, Copyright © 1995 by The Gerontological Society of America

REVIEW, TUTORIAL

Birds as animal models for the comparative biology of aging: a prospectus

DJ Holmes and SN Austad
Department of Biological Sciences, University of Idaho.

Bird species are dramatically longer-lived than similar-sized mammals, in spite of two traits--high metabolic rate and elevated blood glucose-- which some modern theories of aging suggest should be associated with accelerated senescence. As a consequence of their longevity, birds may possess specialized protective mechanisms against free radical and Maillard reaction damage, and may offer insight into medical interventions for retarding aging. In this review we have highlighted a number of bird species which are commercially available, easily maintained, and more thoroughly characterized with respect to basic physiology than many biogerontologists realize. There seem to us to be few intrinsic barriers to the development of several avian "mice"-- extensively characterized species exhibiting exceptionally long life and retarded aging--and for these to become readily accessible as a laboratory resource for the gerontological research community.

This article has been cited by other articles: (Search Google Scholar for Other Citing Articles)

				C. E. Ogburn, K. Carlberg, M. A. Ottinger, D. J. Holmes, G. M. Martin, and S. N. Austad Exceptional Cellular Resistance to Oxidative Damage in Long-Lived Birds Requires Active Gene Expression J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2001; 56(11): B468 - 474. [Abstract] [Full Text] [PDF]

				M. L. Hamilton, Z. Guo, C. D. Fuller, H. Van Remmen, W. F. Ward, S. N. Austad, D. A. Troyer, I. Thompson, and A. Richardson A reliable assessment of 8-oxo-2-deoxyguanosine levels in nuclear and mitochondrial DNA using the sodium iodide method to isolate DNA Nucleic Acids Res., May 15, 2001; 29(10): 2117 - 2126. [Abstract] [Full Text]