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Variables CR Dwarf IGF-1 MR WM NMR Body temperature Reduced Reduced Reduced Reduced Normal Reduced Metabolic rate Reduced/unchanged Reduced NAD NAD NAD Reduced Fasting glucose Reduced Reduced Reduced Reduced NAD Normal GTT Normal Abnormal Abnormal NAD NAD Abnormal Insulin Reduced Reduced Reduced Reduced Reduced Not detected Thyroid hormones Reduced Reduced Reduced Reduced Reduced Reduced % Body fat Reduced Elevated Reduced NAD NAD Normal Repro. maturation Delayed Delayed Delayed NAD Delayed Normal/delayed Repro. fertility Reduced Suppressed Reduced NAD NAD High Cancer incidence Reduced Reduced Reduced NAD NAD Not detected Source of data Longo and Finch, 2003 Longo and Finch, 2003 Longo and Finch, 2003 Miller et al., in press Miller et al., 2002 This study

Note: Experimentally manipulated mice strains (caloric restricted [CR] and methionine restricted [MR]), wild-type mice from Idaho (WM), genetic mutant mice (Ames dwarf mice [dwarf] and insulin-like growth factor-1-deficient mice [IGF-1]), and naked mole-rats (NMR).

NAD = no available data; Repro. = reproductive; GTT = glucose tolerance test.

[Table modified from Longo and Finch (54), with permission.]

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