Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Regazzoni, C. J.
Right arrow Articles by Poderoso, J. J.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Regazzoni, C. J.
Right arrow Articles by Poderoso, J. J.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 63:210-212 (2008)
© 2008 The Gerontological Society of America

BRIEF REPORT

Hospital and 1-Year Outcomes of Septic Syndromes in Older People: A Cohort Study

Carlos Javier Regazzoni, Rafael Jose Zamora, Enrique Petrucci, Ana Andrea Pisarevsky, Ariel Karim Saad, Daniela De Mollein, Carlos Marcelo Luna and Juan Jose Poderoso

1 INECO, Centro de Estudios de la Memoria y Conducta, Buenos Aires, Argentina.
2 Vita Cátedra de Medicina, Hospital de Clínicas, Buenos Aires, Argentina.
3 Hospital de Clínicas and "Laboratorio Metabolismo del Oxígeno," Hospital de Clínicas, Buenos Aires, Argentina.
4 Pulmonary Division, Hospital de Clínicas, Buenos Aires, Argentina.

Address correspondence to Carlos Javier Regazzoni, MD, PhD, INECO, Centro de Estudios de la Memoria y Conducta, Castex 3293 (C1425CDC) Buenos Aires, Argentina. E-mail: cregazzoni{at}intramed.net

Abstract

Purpose. Our objective was to describe the relationship between sepsis syndrome mortality and cognitive and physical disability in elderly persons.

Methods. A 1-year consecutive cohort study in clinical beds of a university hospital was performed. Variables were severity of sepsis syndrome, organ failure, functional status, age, sex, and positive cultures. Outcomes were in-hospital and 1-year mortalities.

Results. The study included 137 patients (>70 years), both sexes. Data from 116 (84.5%) patients were obtainable at 1-year follow-up. Forty-eight (35%) patients presented with sepsis (11/137, 8%) or severe sepsis (37/137, 27%). In-hospital mortality was 15.3% (0% for sepsis and 21.8% if severe) and increased with organ failure (p <.0001). One-year mortality was 54.78% (63/116), mostly related to severe sepsis; predictors were severe organ failure (p <.0001), prior functional status (p =.0005), and Mini-Mental State Examination (p =.03). Prior functional status and organ failure were independent predictors.

Conclusions. In-hospital and 1-year mortality increased with septic syndrome severity, prior functional status, and organ failure.

Key Words: Sepsis—Septic syndrome—Organ failure—Functional capacity






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
All GSA journals The Gerontologist
Journals of Gerontology Series B: Psychological Sciences and Social Sciences
Copyright © 2008 by The Gerontological Society of America.