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Bone Mass of a 113-Year-Old Man

¹ Hospital del Mar, Unidad de Recerca en Fisiopatología Osea i Articular, Institut d' Investigació Medica, Universidad Autónoma de Barcelona, Barcelona, Spain.
² Departament de Genètica, Universitat de Barcelona, Spain.

Address correspondence to Dr. Leonardo Mellibovsky, Hospital del Mar, Internal Medicine, Paseo Maritimo 25-27, Barcelona, 08003, Spain. E-mail: lmellibovsky{at}imas.imim.es

Abstract

Osteoporosis is a common disease that affects elderly people. Aging induces loss of bone density and quality resulting in a progressive incidence of fragility fractures. In this study, we report the bone density of one of the oldest men in the world and of several of his first-degree relatives, as well as a genetic screen of these cases. No fractures have been suffered by any of them, and their bone mineral density (BMD) values in terms of z score were normal or lightly decreased. Neither mutations at the longevity-related gene KLOTHO nor the Gly171Val mutation of LRP5 associated with high bone mass was detected in the two centenarian stepbrothers.