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Association of Interleukin-19 Gene Polymorphisms With Age

¹ Department of Laboratory Medicine, Yamaguchi University Graduate School of Medicine, Japan.
² Division of Clinical Laboratory, Yamaguchi University Hospital, Japan.

Address correspondence to Yuji Hinoda, MD, PhD, Department of Laboratory Medicine, Yamaguchi University Graduate School of Medicine, 1-1-1, Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan. E-mail: hinoda{at}yamaguchi-u.ac.jp

We previously demonstrated a significant association of the interleukin-10 (IL-10) –819 T/C polymorphism with age. IL-19 stimulates the production of IL-10, and the IL-19 gene is located adjacent to the telomere side of the IL-10 gene. To explore the relationship between IL-19 single nucleotide polymorphisms (SNPs) and age, we genotyped 500 Japanese individuals (mean age: 56.7 years, range 19–100) for IL-19 Ser175Phe (T/C), –513 T/C, 1098 G/T (intron 1) and 5420 G/C (5'-untranslated region). Three of four SNPs (Ser175Phe, –513 T/C and 1098 G/T) exhibited a weak but significant association with age by chi-square test and logistic regression analysis (p <.05). IL-19 Ser175Phe was in linkage disequilibrium with –513 T/C and 1098 G/T, but not with IL-10 –819 T/C. These data suggest that IL-19 polymorphisms may be associated with age in a Japanese population.