Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 62:350-351 (2007)
© 2007 The Gerontological Society of America

Genetic Association Between Notch4 Polymorphisms and Alzheimer's Disease in the Japanese Population

Nobuto Shibata, Tohru Ohnuma, Shinji Higashi, Maiko Higashi, Chie Usui, Taku Ohkubo, Tomoko Watanabe, Ritsuko Kawashima, Akiyoshi Kitajima, Akira Ueki, Masatsugu Nagao and Heii Arai

1 Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan.
2 Department of Neurology, Omiya Medical Center, Jichi Medical School, Saitama-shi Japan.
3 Department of Psychiatry, Nagao Hospital, Hiroshima, Japan.

Address correspondence to Nobuto Shibata, MD, Department of Psychiatry, Juntendo University School of Medicine. 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421 Japan. E-mail: nobuto.shibata{at}nifty.ne.jp

It is shown that Notch 4 plays important roles in the pathogenesis of Alzheimer's disease (AD). To investigate whether three single nucleotide polymorphisms (SNPs) of the Notch4 gene are associated with AD, the three SNPs were genotyped by a polymerase chain reaction–restriction fragment length polymorphism method for 243 AD patients and 130 age-matched controls. We also confirmed the linkage disequilibrium among these three SNPs of the gene using the EH program. The three SNPs did not seem to alter risk for AD. Our study suggests that SNPs studied are not associated with AD. The linkage disequilibrium of this locus indicates that there is genetic heterogeneity in the Notch4 gene. We could not confirm the previous synergetic associations of the 5' untranslated region (rs367398) C/C genotype in apolipoprotein E {epsilon}4 bearers in AD patients. Potential markers nearby the 5' untranslated region polymorphism might affect risk for AD.






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